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Target
Bromodomain-containing protein 4 [49-170]
Ligand
BDBM318479
Substrate
n/a
Meas. Tech.
AlphaScreen Assay
IC50
<100±n/a nM
Citation
 Combs, AP; Sparks, RB; Maduskuie, Jr., TP Tricyclic heterocycles as BET protein inhibitors US Patent  US9624241 Publication Date 4/18/2017 
Target
Name:
Bromodomain-containing protein 4 [49-170]
Synonyms:
BRD4 | BRD4-BD1 | BRD4-BD1 (aa 49-170) | BRD4_HUMAN | Bromodomain containing 4 (aa 49-170) | Bromodomain-containing protein 4 (BRD4) | Bromodomain-containing protein 4 (BRD4)(49-170) | Bromodomain-containing protein 4 (BRD4)(BD1) | HUNK1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
14593.14
Organism:
Homo sapiens (Human)
Description:
aa 49-170 (BRD4-BD1)
Residue:
122
Sequence:
ETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEETE
  
Inhibitor
Name:
BDBM318479
Synonyms:
7-(3,5-Dimethylisoxazol-4-yl)-N-isopropyl-4-phenyl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazin-2-amine | US10464947, Example 25 | US11498926, Example 25 | US9624241, Example 25
Type:
Small organic molecule
Emp. Form.:
C23H24N4O2
Mol. Mass.:
388.4623
SMILES:
CC(C)Nc1nc2ccc(-c3c(C)noc3C)c3OCC(c4ccccc4)n1c23 |(4.83,3.44,;4.06,2.1,;4.83,.77,;2.52,2.1,;1.75,.77,;2.88,-.77,;1.54,-1.54,;1.54,-3.08,;.21,-3.85,;-1.13,-3.08,;-2.46,-3.85,;-2.46,-5.39,;-1.13,-6.16,;-3.92,-5.87,;-4.83,-4.62,;-3.92,-3.37,;-4.69,-2.04,;-1.13,-1.54,;-2.46,-.77,;-2.46,.77,;-1.13,1.54,;-1.13,3.08,;.21,3.85,;.21,5.39,;-1.13,6.16,;-2.46,5.39,;-2.46,3.85,;.21,.77,;.21,-.77,)|
Structure:
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