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Target
Type-2 angiotensin II receptor
Ligand
BDBM318769
Substrate
n/a
Meas. Tech.
Receptor Binding Assay
IC50
483±n/a nM
Citation
McCarthy, TD; Naylor, A Heterocyclic compounds and methods of their use US Patent US9624243 Publication Date 4/18/2017
More Info.:
Target
Name:
Type-2 angiotensin II receptor
Synonyms:
AGTR2 | AGTR2_HUMAN | AT2 | Angiotensin II receptor | Angiotensin II type 2 (AT-2) receptor | Angiotensin II, central | Type-2 angiotensin II receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
41201.61
Organism:
Homo sapiens (Human)
Description:
Angiotensin II, central 0 0::P50052
Residue:
363
Sequence:
MKGNSTLATTSKNITSGLHFGLVNISGNNESTLNCSQKPSDKHLDAIPILYYIIFVIGFLVNIVVVTLFCCQKGPKKVSSIYIFNLAVADLLLLATLPLWATYYSYRYDWLFGPVMCKVFGSFLTLNMFASIFFITCMSVDRYQSVIYPFLSQRRNPWQASYIVPLVWCMACLSSLPTFYFRDVRTIEYLGVNACIMAFPPEKYAQWSAGIALMKNILGFIIPLIFIATCYFGIRKHLLKTNSYGKNRITRDQVLKMAAAVVLAFIICWLPFHVLTFLDALAWMGVINSCEVIAVIDLALPFAILLGFTNSCVNPFLYCFVGNRFQQKLRSVFRVPITWLQGKRESMSCRKSSSLREMETFVS
Inhibitor
Name:
BDBM318769
Synonyms:
(2S,4S)-1-(2,2-diphenylacetyl)-4-(methyl((2-phenylcyclopropyl)methyl)amino)pyrrolidine-2-carboxylic acid | US10370388, Compound 63 | US9624243, 63
Type:
Small organic molecule
Emp. Form.:
C30H32N2O3
Mol. Mass.:
468.5867
SMILES:
CN(CC1CC1c1ccccc1)[C@H]1C[C@H](N(C1)C(=O)C(c1ccccc1)c1ccccc1)C(O)=O