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Target
Interleukin-1 receptor-associated kinase 1 [194-712]
Ligand
BDBM318828
Substrate
n/a
Meas. Tech.
Enzymatic Assay
IC50
550±n/a nM
Citation
 Chen, X; Lan, R; Jorand-Lebrun, C; Yu, H; Goutopoulos, A Pyridazinone macrocycles as IRAK inhibitors and uses thereof US Patent  US9624246 Publication Date 4/18/2017 
Target
Name:
Interleukin-1 receptor-associated kinase 1 [194-712]
Synonyms:
IRAK | IRAK1 | IRAK1_HUMAN | Interleukin-1 receptor-associated kinase 1 (IRAK1)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
55943.99
Organism:
Homo sapiens (Human)
Description:
aa 194-712
Residue:
519
Sequence:
RPFPFCWPLCEISRGTHNFSEELKIGEGGFGCVYRAVMRNTVYAVKRLKENADLEWTAVKQSFLTEVEQLSRFRHPNIVDFAGYCAQNGFYCLVYGFLPNGSLEDRLHCQTQACPPLSWPQRLDILLGTARAIQFLHQDSPSLIHGDIKSSNVLLDERLTPKLGDFGLARFSRFAGSSPSQSSMVARTQTVRGTLAYLPEEYIKTGRLAVDTDTFSFGVVVLETLAGQRAVKTHGARTKYLKDLVEEEAEEAGVALRSTQSTLQAGLAADAWAAPIAMQIYKKHLDPRPGPCPPELGLGLGQLACCCLHRRAKRRPPMTQVYERLEKLQAVVAGVPGHSEAASCIPPSPQENSYVSSTGRAHSGAAPWQPLAAPSGASAQAAEQLQRGPNQPVESDESLGGLSAALRSWHLTPSCPLDPAPLREAGCPQGDTAGESSWGSGPGSRPTAVEGLALGSSASSSSEPPQIIINPARQKMVQKLALYEDGALDSLQLLSSSSLPGLGLEQDRQGPEESDEFQS
  
Inhibitor
Name:
BDBM318828
Synonyms:
US10517872, Compound 5 | US9624246, Compound 5
Type:
Small organic molecule
Emp. Form.:
C21H22N6O4
Mol. Mass.:
422.4372
SMILES:
Cn1cc2NC(=O)c3cccc(Cn4nc(OCCCCNC(=O)c2n1)ccc4=O)c3
Structure:
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