Reaction Details Report a problem with these data
Target
Histone deacetylase 4 [2-1084]
Ligand
BDBM187138
Substrate
n/a
Meas. Tech.
HDAC4 Assay
pH
8±n/a
Temperature
298.15±n/a K
IC50
460±n/a nM
Comments
extracted
Citation
 Hebach, C; Kallen, J; Nozulak, J; Tintelnot-Blomley, M; Widler, L Trifluoromethyl-oxadiazole derivatives and their use in the treatment of disease US Patent  US9670193 Publication Date 6/6/2017 
Target
Name:
Histone deacetylase 4 [2-1084]
Synonyms:
HDAC4 (aa 2-1084) | HDAC4 | HDAC4_HUMAN | KIAA0288
Type:
n/a
Mol. Mass.:
118831.12
Organism:
Homo sapiens (Human)
Description:
P56524[2-1084]
Residue:
1082
Sequence:
SQSHPDGLSGRDQPVELLNPARVNHMPSTVDVATALPLQVAPSAVPMDLRLDHQFSLPVAEPALREQQLQQELLALKQKQQIQRQILIAEFQRQHEQLSRQHEAQLHEHIKQQQEMLAMKHQQELLEHQRKLERHRQEQELEKQHREQKLQQLKNKEKGKESAVASTEVKMKLQEFVLNKKKALAHRNLNHCISSDPRYWYGKTQHSSLDQSSPPQSGVSTSYNHPVLGMYDAKDDFPLRKTASEPNLKLRSRLKQKVAERRSSPLLRRKDGPVVTALKKRPLDVTDSACSSAPGSGPSSPNNSSGSVSAENGIAPAVPSIPAETSLAHRLVAREGSAAPLPLYTSPSLPNITLGLPATGPSAGTAGQQDAERLTLPALQQRLSLFPGTHLTPYLSTSPLERDGGAAHSPLLQHMVLLEQPPAQAPLVTGLGALPLHAQSLVGADRVSPSIHKLRQHRPLGRTQSAPLPQNAQALQHLVIQQQHQQFLEKHKQQFQQQQLQMNKIIPKPSEPARQPESHPEETEEELREHQALLDEPYLDRLPGQKEAHAQAGVQVKQEPIESDEEEAEPPREVEPGQRQPSEQELLFRQQALLLEQQRIHQLRNYQASMEAAGIPVSFGGHRPLSRAQSSPASATFPVSVQEPPTKPRFTTGLVYDTLMLKHQCTCGSSSSHPEHAGRIQSIWSRLQETGLRGKCECIRGRKATLEELQTVHSEAHTLLYGTNPLNRQKLDSKKLLGSLASVFVRLPCGGVGVDSDTIWNEVHSAGAARLAVGCVVELVFKVATGELKNGFAVVRPPGHHAEESTPMGFCYFNSVAVAAKLLQQRLSVSKILIVDWDVHHGNGTQQAFYSDPSVLYMSLHRYDDGNFFPGSGAPDEVGTGPGVGFNVNMAFTGGLDPPMGDAEYLAAFRTVVMPIASEFAPDVVLVSSGFDAVEGHPTPLGGYNLSARCFGYLTKQLMGLAGGRIVLALEGGHDLTAICDASEACVSALLGNELDPLPEKVLQQRPNANAVRSMEKVMEIHSKYWRCLQRTTSTAGRSLIEAQTCENEEAETVTAMASLSVGVKPAEKRPDEEPMEEEPPL
  
Inhibitor
Name:
BDBM187138
Synonyms:
US9670193, 1 N-(5-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)pyrazin-2-yl)acetamide
Type:
Small organic molecule
Emp. Form.:
C9H6F3N5O2
Mol. Mass.:
273.1714
SMILES:
CC(=O)Nc1cnc(cn1)-c1noc(n1)C(F)(F)F
Structure:
Search PDB for entries with ligand similarity: