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Target5-hydroxytryptamine receptor 1A (5-HT1A)
LigandBDBM319746
Substrate/Competitorn/a
Meas. Tech.5-HT1A Receptor Agonism Activity Test
EC50 0.766±n/a nM
Citation Jiang, HWang, ZLi, JZhang, RHe, YLiu, YBi, MLiu, ZTian, GChen, WYang, FWu, CWang, YJiang, XYin, JWang, GShen, J Heterocyclic compounds, process for preparation of the same and use thereof US Patent US10174011 Publication Date 1/8/2019
More Info.:Get all data from this article,  Assay Method
 
5-hydroxytryptamine receptor 1A (5-HT1A)
Name:5-hydroxytryptamine receptor 1A (5-HT1A)
Synonyms:5-HT-1A | 5-HT1A | 5-hydroxytryptamine receptor 1A | 5-hydroxytryptamine receptor 1A (5-HT-1A) | ADRB2RL1 | ADRBRL1 | Dopamine D2 receptor and serotonin 1a receptor | G-21 | HTR1A | Serotonin receptor 1A
Type:n/a
Mol. Mass.:46122.49
Organism:Homo sapiens (human)
Description:n/a
Residue:422
Sequence:
MDVLSPGQGNNTTSPPAPFETGGNTTGISDVTVSYQVITSLLLGTLIFCAVLGNACVVAA
IALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCC
TSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPED
RSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVKKVEKTGADT
RHGASPAPQPKKSVNGESGSRNWRLGVESKAGGALCANGAVRQGDDGAALEVIEVHRVGN
SKEHLPLPSEAGPTPCAPASFERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLP
FFIVALVLPFCESSCHMPTLLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFC
RQ
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  Blast E-value cutoff:
BDBM319746
NameBDBM319746
Synonyms:6-(2-(4-(benzo[b]thiophen-4-yl)piperazin-1-yl)ethyl)-8-fluoro2H-benzo[b][1,4]oxazin-3(4H)-one | US10174011, Example 139
TypeSmall organic molecule
Emp. Form.C22H22FN3O2S
Mol. Mass.411.492
SMILESFc1cc(CCN2CCN(CC2)c2cccc3sccc23)cc2NC(=O)COc12
Structure
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n/a