Reaction Details Report a problem with these data
Target
Fatty-acid amide hydrolase 1
Ligand
BDBM319811
Substrate
n/a
Meas. Tech.
Determining Endocannabinoid Hydrolase Activity
IC50
>100000±n/a nM
Citation
 Liu, Z; Qiu, Y; Ren, J; Li, Y; Yang, L; Zhu, C Substituted heterocyclic derivative, preparation method and use thereof US Patent  US10174015 Publication Date 1/8/2019 
Target
Name:
Fatty-acid amide hydrolase 1
Synonyms:
Anandamide amidohydrolase | Anandamide amidohydrolase 1 | FAAH | FAAH1 | FAAH1_HUMAN | Fatty Acid Amide Hydrolase (FAAH) | Fatty-acid amide hydrolase (FAAH) | Fatty-acid amide hydrolase 1 | Oleamide hydrolase 1
Type:
Protein
Mol. Mass.:
63071.19
Organism:
Homo sapiens (Human)
Description:
O00519
Residue:
579
Sequence:
MVQYELWAALPGASGVALACCFVAAAVALRWSGRRTARGAVVRARQRQRAGLENMDRAAQRFRLQNPDLDSEALLALPLPQLVQKLHSRELAPEAVLFTYVGKAWEVNKGTNCVTSYLADCETQLSQAPRQGLLYGVPVSLKECFTYKGQDSTLGLSLNEGVPAECDSVVVHVLKLQGAVPFVHTNVPQSMFSYDCSNPLFGQTVNPWKSSKSPGGSSGGEGALIGSGGSPLGLGTDIGGSIRFPSSFCGICGLKPTGNRLSKSGLKGCVYGQEAVRLSVGPMARDVESLALCLRALLCEDMFRLDPTVPPLPFREEVYTSSQPLRVGYYETDNYTMPSPAMRRAVLETKQSLEAAGHTLVPFLPSNIPHALETLSTGGLFSDGGHTFLQNFKGDFVDPCLGDLVSILKLPQWLKGLLAFLVKPLLPRLSAFLSNMKSRSAGKLWELQHEIEVYRKTVIAQWRALDLDVVLTPMLAPALDLNAPGRATGAVSYTMLYNCLDFPAGVVPVTTVTAEDEAQMEHYRGYFGDIWDKMLQKGMKKSVGLPVAVQCVALPWQEELCLRFMREVERLMTPEKQSS
  
Inhibitor
Name:
BDBM319811
Synonyms:
US10174015, Compound 24
Type:
Small organic molecule
Emp. Form.:
C17H21NO3
Mol. Mass.:
287.3535
SMILES:
O=C(C1CCC(Cc2ccccc2)CC1)N1CCOC1=O |(2.82,2.31,;2.82,.77,;1.48,,;.15,.77,;-1.18,,;-1.18,-1.54,;-2.52,-2.31,;-3.85,-1.54,;-3.85,,;-5.19,.77,;-6.52,,;-6.52,-1.54,;-5.19,-2.31,;.15,-2.31,;1.48,-1.54,;4.15,,;4.15,-1.54,;5.61,-2.02,;6.52,-.77,;5.61,.48,;6.38,1.81,)|
Structure:
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