Target

Ligand

Substrate

Meas. Tech.

Carbonic Anhydrase Enzyme Inhibition Assay

Ki

>100000±n/a nM

Citation

 Scozzafava, A; Supuran, CT Carbonic anhydrase and matrix metalloproteinase inhibitors: sulfonylated amino acid hydroxamates with MMP inhibitory properties act as efficient inhibitors of CA isozymes I, II, and IV, and N-hydroxysulfonamides inhibit both these zinc enzymes. J Med Chem 43:3677-87 (2000) [PubMed]  Article Copy BDB DOI

More Info.:

Get all data from this article,   Solution Info,  Assay Method

Name:

Interstitial collagenase

Synonyms:

CLG | Fibroblast collagenase | MMP1 | MMP1_HUMAN | Matrix metalloproteinase-1 | Matrix metalloproteinase-1 (MMP-1)

Type:

Enzyme

Mol. Mass.:

54010.26

Organism:

Homo sapiens (Human)

Description:

P03956

Residue:

469

Sequence:

MHSFPPLLLLLFWGVVSHSFPATLETQEQDVDLVQKYLEKYYNLKNDGRQVEKRRNSGPVVEKLKQMQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIENYTPDLPRADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGNLAHAFQPGPGIGGDAHFDEDERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSYTFSGDVQLAQDDIDGIQAIYGRSQNPVQPIGPQTPKACDSKLTFDAITTIRGEVMFFKDRFYMRTNPFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGYPKDIYSSFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFPGIGHKVDAVFMKDGFFYFFHGTRQYKFDPKTKRILTLQKANSWFNCRKN

Blast this sequence in BindingDB or PDB

  
Blast E-value cutoff:

Name:

BDBM11370

Synonyms:

(hydroxysulfamoyl)dimethylamine | Hydroxysulfonamide 51

Type:

Small organic molecule

Emp. Form.:

C2H8N2O3S

Mol. Mass.:

140.162

SMILES:

CN(C)S(=O)(=O)NO

Structure:

Search PDB for entries with ligand similarity:

Similarity to this molecule at least:

Name:

BDBM11446

Synonyms:

AcProLeuGly-S-LeuLeuGlyOEt | MMP Thioester Substrate

Type:

n/a

Emp. Form.:

n/a

Mol. Mass.:

n/a

SMILES:

n/a

Structure: