Target

Ligand

Substrate

Meas. Tech.

Carbonic Anhydrase Enzyme Inhibition Assay

Ki

12000±n/a nM

Citation

 Scozzafava, A; Supuran, CT Carbonic anhydrase and matrix metalloproteinase inhibitors: sulfonylated amino acid hydroxamates with MMP inhibitory properties act as efficient inhibitors of CA isozymes I, II, and IV, and N-hydroxysulfonamides inhibit both these zinc enzymes. J Med Chem 43:3677-87 (2000) [PubMed]  Article Copy BDB DOI

More Info.:

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Name:

Neutrophil collagenase

Synonyms:

CLG1 | MMP-8 | MMP8 | MMP8_HUMAN | Matrix metalloproteinase-8 | Neutrophil collagenase precursor | PMNL collagenase | PMNL-CL

Type:

Enzyme

Mol. Mass.:

53413.48

Organism:

Homo sapiens (Human)

Description:

P22894

Residue:

467

Sequence:

MFSLKTLPFLLLLHVQISKAFPVSSKEKNTKTVQDYLEKFYQLPSNQYQSTRKNGTNVIVEKLKEMQRFFGLNVTGKPNEETLDMMKKPRCGVPDSGGFMLTPGNPKWERTNLTYRIRNYTPQLSEAEVERAIKDAFELWSVASPLIFTRISQGEADINIAFYQRDHGDNSPFDGPNGILAHAFQPGQGIGGDAHFDAEETWTNTSANYNLFLVAAHEFGHSLGLAHSSDPGALMYPNYAFRETSNYSLPQDDIDGIQAIYGLSSNPIQPTGPSTPKPCDPSLTFDAITTLRGEILFFKDRYFWRRHPQLQRVEMNFISLFWPSLPTGIQAAYEDFDRDLIFLFKGNQYWALSGYDILQGYPKDISNYGFPSSVQAIDAAVFYRSKTYFFVNDQFWRYDNQRQFMEPGYPKSISGAFPGIESKVDAVFQQEHFFHVFSGPRYYAFDLIAQRVTRVARGNKWLNCRYG

Blast this sequence in BindingDB or PDB

  
Blast E-value cutoff:

Name:

BDBM11382

Synonyms:

Hydroxysulfonamide 63 | N-[4-(hydroxysulfamoyl)phenyl]acetamide

Type:

Small organic molecule

Emp. Form.:

C8H10N2O4S

Mol. Mass.:

230.241

SMILES:

CC(=O)Nc1ccc(cc1)S(=O)(=O)NO

Structure:

Search PDB for entries with ligand similarity:

Similarity to this molecule at least:

Name:

BDBM11446

Synonyms:

AcProLeuGly-S-LeuLeuGlyOEt | MMP Thioester Substrate

Type:

n/a

Emp. Form.:

n/a

Mol. Mass.:

n/a

SMILES:

n/a

Structure: