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Target
NEDD8-conjugating enzyme UBE2F
Ligand
BDBM321040
Substrate
n/a
Meas. Tech.
Nedd8 Conjugation Inhibitory Activity
IC50
4.30±n/a nM
Citation
 Mizutani, T; Yoshimura, C; Kondo, H; Kitade, M; Ohkubo, S Pyrrolopyrimidine compound or salt thereof and compositions containing the pyrrolopyrimidine compound or salt thereof US Patent  US10174040 Publication Date 1/8/2019 
Target
Name:
NEDD8-conjugating enzyme UBE2F
Synonyms:
NCE2 | NEDD8 carrier protein UBE2F | NEDD8 protein ligase UBE2F | NEDD8-conjugating enzyme 2 | RING-type E3 NEDD8 transferase UBE2F | UBE2F | UBE2F_HUMAN | Ubiquitin-conjugating enzyme E2 F
Type:
Enzyme Catalytic Domain
Mol. Mass.:
21077.76
Organism:
Homo sapiens (Human)
Description:
Q969M7
Residue:
185
Sequence:
MLTLASKLKRDDGLKGSRTAATASDSTRRVSVRDKLLVKEVAELEANLPCTCKVHFPDPNKLHCFQLTVTPDEGYYQGGKFQFETEVPDAYNMVPPKVKCLTKIWHPNITETGEICLSLLREHSIDGTGWAPTRTLKDVVWGLNSLFTDLLNFDDPLNIEAAEHHLRDKEDFRNKVDDYIKRYAR
  
Inhibitor
Name:
BDBM321040
Synonyms:
4-Amino-5-[2-[2,6-difluoro-4-[(3R)-3-hydroxypyrrolidin-1-yl]phenyl]ethynyl]-7-[(1R,2S,3R,4R)-2,3-dihydroxy-4-[(sulfamoylamino)methyl]cyclopentyl]pyrrolo[2,3-d]pyrimidine | US10174040, Example 120 | US9963456, Example 120
Type:
Small organic molecule
Emp. Form.:
C24H27F2N7O5S
Mol. Mass.:
563.577
SMILES:
Nc1ncnc2n(cc(C#Cc3c(F)cc(cc3F)N3CC[C@@H](O)C3)c12)[C@@H]1C[C@H](CNS(N)(=O)=O)[C@@H](O)[C@H]1O
Structure:
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