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TargetNEDD8-conjugating enzyme UBE2F
LigandBDBM321044
Substrate/Competitorn/a
Meas. Tech.Nedd8 Conjugation Inhibitory Activity
IC50 19.0±n/a nM
Citation Mizutani, TYoshimura, CKondo, HKitade, MOhkubo, S Pyrrolopyrimidine compound or salt thereof and compositions containing the pyrrolopyrimidine compound or salt thereof US Patent US10174040 Publication Date 1/8/2019
More Info.:Get all data from this article,  Assay Method
 
NEDD8-conjugating enzyme UBE2F
Name:NEDD8-conjugating enzyme UBE2F
Synonyms:NCE2 | NEDD8 carrier protein UBE2F | NEDD8 protein ligase UBE2F | NEDD8-conjugating enzyme 2 | RING-type E3 NEDD8 transferase UBE2F | UBE2F | Ubiquitin-conjugating enzyme E2 F
Type:Enzyme Catalytic Domain
Mol. Mass.:21077.76
Organism:Homo sapiens (Human)
Description:Q969M7
Residue:185
Sequence:
MLTLASKLKRDDGLKGSRTAATASDSTRRVSVRDKLLVKEVAELEANLPCTCKVHFPDPN
KLHCFQLTVTPDEGYYQGGKFQFETEVPDAYNMVPPKVKCLTKIWHPNITETGEICLSLL
REHSIDGTGWAPTRTLKDVVWGLNSLFTDLLNFDDPLNIEAAEHHLRDKEDFRNKVDDYI
KRYAR
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  Blast E-value cutoff:
BDBM321044
NameBDBM321044
Synonyms:4-Amino-5-[2-(2-ethoxy-6-fluoro-phenyl)ethynyl]-7-[(2R,4S,5R)-4-hydroxy-5-[(sulfamoylamino)methyl]tetrahydrofuran-2-yl]pyrrolo[2,3-d]pyrimidine | US10174040, Example 127
TypeSmall organic molecule
Emp. Form.C21H23FN6O5S
Mol. Mass.490.508
SMILESCCOc1cccc(F)c1C#Cc1cn([C@H]2C[C@H](O)[C@@H](CNS(N)(=O)=O)O2)c2ncnc(N)c12
Structure
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