Target
Tyrosine-protein kinase SYK
Ligand
BDBM189862
Substrate
n/a
Meas. Tech.
Time-Resolved Fluorescence (HTRF) Assay
pH
7.5±n/a
Temperature
298.15±n/a K
IC50
5.4±0.0 nM
Comments
extracted
Citation
 Miller, TAPetrocchi, ARomeo, ETVitharana, DKattar, SDNorthrup, ABAltman, MDAnthony, NJ Thiazole-substituted aminoheteroaryls as Spleen Tyrosine Kinase inhibitors US Patent  US9670196 Publication Date 6/6/2017 
Target
Name:
Tyrosine-protein kinase SYK
Synonyms:
KSYK_HUMAN | SYK | Spleen Tyrosine Kinase | Spleen tyrosine kinase (SYK) | Tyrosine-protein kinase SYK (Syk)
Type:
Enzyme
Mol. Mass.:
72079.99
Organism:
Homo sapiens (Human)
Description:
P43405
Residue:
635
Sequence:
MASSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPFEDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPATWSAGGIISRIKSYSFPKPGHRKSSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN
  
Inhibitor
Name:
BDBM189862
Synonyms:
US9670196, 1.6 4-(1-(5-(6-((1H- pyrrolo[2,3-b]pyridin-6- yl)amino)-4- methylpyridin-2- yl)thiazol-2-yl)-1- hydroxyethyl)benzoic acid
Type:
Small organic molecule
Emp. Form.:
C25H21N5O3S
Mol. Mass.:
471.531
SMILES:
Cc1cc(Nc2ccc3cc[nH]c3n2)nc(c1)-c1cnc(s1)C(C)(O)c1ccc(cc1)C(O)=O
Structure:
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