Target
Histone-lysine N-methyltransferase SMYD3
Ligand
BDBM321287
Substrate
n/a
Meas. Tech.
SMYD3 biochemical assay
IC50
>10000±n/a nM
Citation
 Chesworth, RFoley, MAKuntz, KWMitchell, LHPetter, JCSchwartz, CE Isoxazole carboxamides as irreversible SMYD inhibitors US Patent  US10179773 Publication Date 1/15/2019 
Target
Name:
Histone-lysine N-methyltransferase SMYD3
Synonyms:
SET and MYND domain-containing protein 3 | SMYD3 | SMYD3_HUMAN | ZMYND1 | ZNFN3A1 | Zinc finger MYND domain-containing protein 1
Type:
Enzyme
Mol. Mass.:
49101.22
Organism:
Homo sapiens (Human)
Description:
Q9H7B4-2
Residue:
428
Sequence:
MEPLKVEKFATAKRGNGLRAVTPLRPGELLFRSDPLAYTVCKGSRGVVCDRCLLGKEKLMRCSQCRVAKYCSAKCQKKAWPDHKRECKCLKSCKPRYPPDSVRLLGRVVFKLMDGAPSESEKLYSFYDLESNINKLTEDKKEGLRQLVMTFQHFMREEIQDASQLPPAFDLFEAFAKVICNSFTICNAEMQEVGVGLYPSISLLNHSCDPNCSIVFNGPHLLLRAVRDIEVGEELTICYLDMLMTSEERRKQLRDQYCFECDCFRCQTQDKDADMLTGDEQVWKEVQESLKKIEELKAHWKWEQVLAMCQAIISSNSERLPDINIYQLKVLDCAMDACINLGLLEEALFYGTRTMEPYRIFFPGSHPVRGVQVMKVGKLQLHQGMFPQAMKNLRLAFDIMRVTHGREHSLIEDLILLLEECDANIRAS
  
Inhibitor
Name:
BDBM321287
Synonyms:
5-cyclopropyl-N-(1- (vinylsulfonyl)azetidin-3-yl) isoxazole-3-carboxamide | US10179773, Compound 1 | US10669243, Compound 1
Type:
Small organic molecule
Emp. Form.:
C12H15N3O4S
Mol. Mass.:
297.33
SMILES:
C=CS(=O)(=O)N1CC(C1)NC(=O)c1cc(on1)C1CC1
Structure:
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