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TargetBRD4 BD1 (aa 42-168)
LigandBDBM321354
Substrate/Competitorn/a
Meas. Tech.IC50 Measurements for Inhibitors Using BRD4 AlphaLisa Binding Assay
IC50 830±n/a nM
Citation Albrecht, BKBellon, SFBurdick, DJCote, ACrawford, TDakin, LAHsiao-Wei Tsui, VHewitt, MCLeBlanc, YMagnuson, SRNasveschuk, CGRomero, FATang, YTaylor, AMWang, S Therapeutic compounds and uses thereof US Patent US10183009 Publication Date 1/22/2019
More Info.:Get all data from this article,  Assay Method
 
BRD4 BD1 (aa 42-168)
Name:BRD4 BD1 (aa 42-168)
Synonyms:Bromodomain-containing protein 4 Bromo Domain 1
Type:Enzyme Catalytic Domain
Mol. Mass.:15054.68
Organism:Homo sapiens (human)
Description:n/a
Residue:127
Sequence:
STNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKII
KTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKI
NELPTEE
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  Blast E-value cutoff:
BDBM321354
NameBDBM321354
Synonyms:3-(6-but-2-enyl-7-oxo-1H-pyrrolo[2,3-c]pyridin-4-yl)-N-cyclopropyl-benzamide | US10183009, Example 26
TypeSmall organic molecule
Emp. Form.C21H21N3O2
Mol. Mass.347.4103
SMILESCC=CCn1cc(-c2cccc(c2)C(=O)NC2CC2)c2cc[nH]c2c1=O
Structure
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n/a