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Target
Bromodomain-containing protein 4 [42-168]
Ligand
BDBM321362
Substrate
n/a
Meas. Tech.
IC50 Measurements for Inhibitors Using BRD4 AlphaLisa Binding Assay
IC50
8400±n/a nM
Citation
 Albrecht, BK; Bellon, SF; Burdick, DJ; Cote, A; Crawford, T; Dakin, LA; Hsiao-Wei Tsui, V; Hewitt, MC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM; Wang, S Therapeutic compounds and uses thereof US Patent  US10183009 Publication Date 1/22/2019 
Target
Name:
Bromodomain-containing protein 4 [42-168]
Synonyms:
BRD4 | BRD4 BD1 (aa 42-168) | BRD4_HUMAN | Bromodomain-containing protein 4 Bromo Domain 1 | HUNK1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
15054.68
Organism:
Homo sapiens (Human)
Description:
O60885[42-168]
Residue:
127
Sequence:
STNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEE
  
Inhibitor
Name:
BDBM321362
Synonyms:
6-(2-furylmethyl)-4-phenyl-1H-pyrrolo[2,3-c]pyridin-7-one | US10183009, Example 45
Type:
Small organic molecule
Emp. Form.:
C18H14N2O2
Mol. Mass.:
290.316
SMILES:
O=c1n(Cc2ccco2)cc(-c2ccccc2)c2cc[nH]c12
Structure:
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