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TargetBRD4 BD1 (aa 42-168)
LigandBDBM321366
Substrate/Competitorn/a
Meas. Tech.IC50 Measurements for Inhibitors Using BRD4 AlphaLisa Binding Assay
IC50 1300±n/a nM
Citation Albrecht, BKBellon, SFBurdick, DJCote, ACrawford, TDakin, LAHsiao-Wei Tsui, VHewitt, MCLeBlanc, YMagnuson, SRNasveschuk, CGRomero, FATang, YTaylor, AMWang, S Therapeutic compounds and uses thereof US Patent US10183009 Publication Date 1/22/2019
More Info.:Get all data from this article,  Assay Method
 
BRD4 BD1 (aa 42-168)
Name:BRD4 BD1 (aa 42-168)
Synonyms:Bromodomain-containing protein 4 Bromo Domain 1
Type:Enzyme Catalytic Domain
Mol. Mass.:15054.68
Organism:Homo sapiens (Human)
Description:n/a
Residue:127
Sequence:
STNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKII
KTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKI
NELPTEE
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  Blast E-value cutoff:
BDBM321366
NameBDBM321366
Synonyms:3-[6-[(E)-but-2-enyl]-7-oxo-1H-pyrrolo[2,3-c]pyridin-4-yl]-N-cyclobutyl-4-methoxy-benzamide | US10183009, Example 75
TypeSmall organic molecule
Emp. Form.C23H25N3O3
Mol. Mass.391.4629
SMILESCOc1ccc(cc1-c1cn(C\C=C\C)c(=O)c2[nH]ccc12)C(=O)NC1CCC1
Structure
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n/a