Reaction Details Report a problem with these data
Target
Chromatin remodeling regulator CECR2 [424-538]
Ligand
BDBM321469
Substrate
n/a
Meas. Tech.
IC50 Measurements for Inhibitors Using TAF1-BD2 TR-FRET Binding Assay
IC50
20.0±n/a nM
Citation
Albrecht, BK; Bellon, SF; Burdick, DJ; Cote, A; Crawford, T; Dakin, LA; Hsiao-Wei Tsui, V; Hewitt, MC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM; Wang, S Therapeutic compounds and uses thereof US Patent US10183009 Publication Date 1/22/2019
More Info.:
Target
Name:
Chromatin remodeling regulator CECR2 [424-538]
Synonyms:
CECR2 | CECR2 (aa 424-538) | CECR2_HUMAN | Cat eye syndrome critical region protein 2 [424-538] | KIAA1740
Type:
Enzyme Catalytic Domain
Mol. Mass.:
13747.10
Organism:
Homo sapiens (Human)
Description:
Q9BXF3[424-538]
Residue:
115
Sequence:
MREEKKTKDLFELDDDFTAMYKVLDVVKAHKDSWPFLEPVDESYAPNYYQIIKAPMDISSMEKKLNGGLYCTKEEFVNDMKTMFRNCRKYNGESSEYTKMSDNLERCFHRAMMKH
Inhibitor
Name:
BDBM321469
Synonyms:
4-(6-(but-3-en-1-yl)-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)-N,N-dimethyl-1H-benzo[d]imidazole-6-carboxamide | US10183009, Example 61
Type:
Small organic molecule
Emp. Form.:
C21H21N5O2
Mol. Mass.:
375.4237
SMILES:
CN(C)C(=O)c1cc(-c2cn(CCC=C)c(=O)c3[nH]ccc23)c2nc[nH]c2c1