Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetCarbonic anhydrase 2
LigandBDBM11421
Substrate/CompetitorBDBM11402
Meas. Tech.In vitro binding of inhibitor to hCA-II
Ki 0.11±n/a nM
Citation Chen, HHGross, SLiao, JMcLaughlin, MDean, TSly, WSMay, JA 2H-Thieno[3,2-e]- and [2,3-e]-1,2-thiazine-6-sulfonamide 1,1-dioxides as ocular hypotensive agents: synthesis, carbonic anhydrase inhibition and evaluation in the rabbit. Bioorg Med Chem8:957-75 (2000) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Carbonic anhydrase 2
Name:Carbonic anhydrase 2
Synonyms:CA-II | CA2 | CAC | Carbonate dehydratase II | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase 2 (CA-II) | Carbonic anhydrase 2 (Recombinant CA II) | Carbonic anhydrase C | Carbonic anhydrase II (CA II) | Carbonic anhydrase II (CA-II) | Carbonic anhydrase II (CAII) | Carbonic anhydrase II (hCA II) | Carbonic anhydrase isoenzyme II (hCA II)
Type:Enzyme
Mol. Mass.:29250.71
Organism:Homo sapiens (human)
Description:P00918
Residue:260
Sequence:
MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRIL
NNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHL
VHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDP
RGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELM
VDNWRPAQPLKNRQIKASFK
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM11421
NameBDBM11421
Synonyms:2-(3-Methoxyphenyl)-3-[(2-hydroxyethylamino)methyl]-2H-thieno[3,2-e]-1,2-thiazine-6-sulfonamide 1,1-dioxide hydrochloride | 2H-Thieno[3,2-e]-1,2-thiazine-6-sulfonamide 1,1-dioxide 28 | 3-{[(2-hydroxyethyl)amino]methyl}-2-(3-methoxyphenyl)-1,1-dioxo-2H-1,7,2-thieno[3,2-e][1,2]thiazine-6-sulfonamide hydrochloride | Compound 17k5
TypeSmall organic molecule
Emp. Form.C16H19N3O6S3
Mol. Mass.445.534
SMILESCOc1cccc(c1)N1C(CNCCO)=Cc2cc(sc2S1(=O)=O)S(N)(=O)=O |c:15|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
BDBM11402
NameBDBM11402
Synonyms:5-(dimethylamino)naphthalene-1-sulfonamide | dansylamide
TypeSmall organic molecule
Emp. Form.C12H14N2O2S
Mol. Mass.250.317
SMILESCN(C)c1cccc2c(cccc12)S(N)(=O)=O
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: