Reaction Details Report a problem with these data
Target
5-hydroxytryptamine receptor 3A
Ligand
BDBM322365
Substrate
n/a
Meas. Tech.
[3H]BRL 43694 Competition Binding (h-5HT3 Assay
Ki
440±n/a nM
Citation
Acharya, R; Burnett, DA; Bursavich, MG; Cook, AS; Harrison, BA; Koenig, G; Mcriner, AJ Geminal substituted quinuclidine amide compounds as agonists of α-7 nicotonic acetylcholine receptors US Patent US10183938 Publication Date 1/22/2019
More Info.:
Target
Name:
5-hydroxytryptamine receptor 3A
Synonyms:
5-HT-3 | 5-HT3 | 5-HT3A | 5-HT3R | 5-hydroxytryptamine receptor 3 (5-HT3) | 5-hydroxytryptamine receptor 3A (5-HT3a) | 5-hydroxytryptamine receptor 3A (5HT3A) | 5HT3A_HUMAN | 5HT3R | HTR3 | HTR3A | Serotonin 3 (5-HT3) receptor | Serotonin 3 receptor (5HT3) | Serotonin receptor 3A | Serotonin-gated ion channel receptor | Serotonin-gated ion channel receptor 3
Type:
Protein
Mol. Mass.:
55283.27
Organism:
Homo sapiens (Human)
Description:
P46098
Residue:
478
Sequence:
MLLWVQQALLALLLPTLLAQGEARRSRNTTRPALLRLSDYLLTNYRKGVRPVRDWRKPTTVSIDVIVYAILNVDEKNQVLTTYIWYRQYWTDEFLQWNPEDFDNITKLSIPTDSIWVPDILINEFVDVGKSPNIPYVYIRHQGEVQNYKPLQVVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINISLWRLPEKVKSDRSVFMNQGEWELLGVLPYFREFSMESSNYYAEMKFYVVIRRRPLFYVVSLLLPSIFLMVMDIVGFYLPPNSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVRLVHKQDLQQPVPAWLRHLVLERIAWLLCLREQSTSQRPPATSQATKTDDCSAMGNHCSHMGGPQDFEKSPRDRCSPPPPPREASLAVCGLLQELSSIRQFLEKRDEIREVARDWLRVGSVLDKLLFHIYLLAVLAYSITLVMLWSIWQYA
Inhibitor
Name:
BDBM322365
Synonyms:
(R)-N-(2,2-dimethylquinuclidin-3-yl)-7-(thiazol-2-yl)benzo[b]thiophene-2-carboxamide | US10183938, Compound (R)-129
Type:
Small organic molecule
Emp. Form.:
C21H23N3OS2
Mol. Mass.:
397.557
SMILES:
CC1(C)[C@H](NC(=O)c2cc3cccc(-c4nccs4)c3s2)C2CCN1CC2 |wD:3.3,(3.67,-3.49,;3.67,-1.95,;2.34,-2.72,;2.9,-.62,;1.36,-.62,;.59,-1.95,;1.36,-3.29,;-.95,-1.95,;-1.85,-3.2,;-3.32,-2.72,;-4.65,-3.49,;-5.98,-2.72,;-5.98,-1.18,;-4.65,-.41,;-4.65,1.13,;-5.9,2.03,;-5.42,3.49,;-3.88,3.49,;-3.4,2.03,;-3.32,-1.18,;-1.85,-.71,;3.67,.71,;4.71,.2,;5.28,-.8,;5.21,-1.95,;5.98,-.62,;5.21,.71,)|