Reaction Details Report a problem with these data
Target
5-hydroxytryptamine receptor 3A
Ligand
BDBM322356
Substrate
n/a
Meas. Tech.
[3H]BRL 43694 Competition Binding (h-5HT3 Assay
Ki
895±n/a nM
Citation
 Acharya, R; Burnett, DA; Bursavich, MG; Cook, AS; Harrison, BA; Koenig, G; Mcriner, AJ Geminal substituted quinuclidine amide compounds as agonists of α-7 nicotonic acetylcholine receptors US Patent  US10183938 Publication Date 1/22/2019 
Target
Name:
5-hydroxytryptamine receptor 3A
Synonyms:
5-HT-3 | 5-HT3 | 5-HT3A | 5-HT3R | 5-hydroxytryptamine receptor 3 (5-HT3) | 5-hydroxytryptamine receptor 3A (5-HT3a) | 5-hydroxytryptamine receptor 3A (5HT3A) | 5HT3A_HUMAN | 5HT3R | HTR3 | HTR3A | Serotonin 3 (5-HT3) receptor | Serotonin 3 receptor (5HT3) | Serotonin receptor 3A | Serotonin-gated ion channel receptor | Serotonin-gated ion channel receptor 3
Type:
Protein
Mol. Mass.:
55283.27
Organism:
Homo sapiens (Human)
Description:
P46098
Residue:
478
Sequence:
MLLWVQQALLALLLPTLLAQGEARRSRNTTRPALLRLSDYLLTNYRKGVRPVRDWRKPTTVSIDVIVYAILNVDEKNQVLTTYIWYRQYWTDEFLQWNPEDFDNITKLSIPTDSIWVPDILINEFVDVGKSPNIPYVYIRHQGEVQNYKPLQVVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINISLWRLPEKVKSDRSVFMNQGEWELLGVLPYFREFSMESSNYYAEMKFYVVIRRRPLFYVVSLLLPSIFLMVMDIVGFYLPPNSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVRLVHKQDLQQPVPAWLRHLVLERIAWLLCLREQSTSQRPPATSQATKTDDCSAMGNHCSHMGGPQDFEKSPRDRCSPPPPPREASLAVCGLLQELSSIRQFLEKRDEIREVARDWLRVGSVLDKLLFHIYLLAVLAYSITLVMLWSIWQYA
  
Inhibitor
Name:
BDBM322356
Synonyms:
(R)-N-(1''-azaspiro[cyclopropane-1,2''-bicyclo[2.2.2]octan]-3''-yl)-7-(trifluoromethoxy)benzo[b]thiophene-2-carboxamide | US10183938, Compound (R)-120 | US10183938, Compound (R)-167
Type:
Small organic molecule
Emp. Form.:
C19H19F3N2O2S
Mol. Mass.:
396.427
SMILES:
FC(F)(F)Oc1cccc2cc(sc12)C(=O)N[C@@H]1C2CCN(CC2)C11CC1
Structure:
Search PDB for entries with ligand similarity: