Reaction Details Report a problem with these data
Target
RAF proto-oncogene serine/threonine-protein kinase [Y340D,Y341D]
Ligand
BDBM322521
Substrate
n/a
IC50
<4±n/a nM
Citation
 Bingham, M; Testar, R; Gignoux, C Fused bicyclic (hetero)aromatic compounds useful for the treatment of cancers US Patent  US10183939 Publication Date 1/22/2019 
Target
Name:
RAF proto-oncogene serine/threonine-protein kinase [Y340D,Y341D]
Synonyms:
C-RAF (Y340D Y341D) | RAF | RAF proto-oncogene serine/threonine-protein kinase (Y340D/Y341D) | RAF proto-oncogene serine/threonine-protein kinase (c-Raf)(Y340D)(Y341D) | RAF1 | RAF1_HUMAN
Type:
Serine/threonine-protein kinase
Mol. Mass.:
72984.33
Organism:
Homo sapiens (Human)
Description:
P04049 Y340D Y341D
Residue:
648
Sequence:
MEHIQGAWKTISNGFGFKDAVFDGSSCISPTIVQQFGYQRRASDDGKLTDPSKTSNTIRVFLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDAASLIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKVPTMCVDWSNIRQLLLFPNSTIGDSGVPALPSLTMRRMRESVSRMPVSSQHRYSTPHAFTFNTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIEDAIRSHSESASPSALSSSPNNLSPTGWSQPKTPVPAQRERAPVSGTQEKNKIRPRGQRDSSDDWEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLTTSPRLPVF
  
Inhibitor
Name:
BDBM322521
Synonyms:
5-[3-(4-phenyl-1H-imidazol-2-yl)chroman-6-yl]oxy-3,4-dihydro-1H-1,8-naphthyridin-2-one] | US10183939, Example 3 | US10183939, Example 3A | US10183939, Example 3B | USRE49361, Example 3B
Type:
Small organic molecule
Emp. Form.:
C26H22N4O3
Mol. Mass.:
438.4779
SMILES:
O=C1CCc2c(Oc3ccc4OCC(Cc4c3)c3nc(c[nH]3)-c3ccccc3)ccnc2N1
Structure:
Search PDB for entries with ligand similarity: