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TargetC-RAF (Y340D Y341D)
LigandBDBM322540
Substrate/Competitorn/a
IC50<4±n/a nM
Citation Bingham, MTestar, RGignoux, C Fused bicyclic (hetero)aromatic compounds useful for the treatment of cancers US Patent US10183939 Publication Date 1/22/2019
More Info.:Get all data from this article,  Assay Method
 
C-RAF (Y340D Y341D)
Name:C-RAF (Y340D Y341D)
Synonyms:RAF proto-oncogene serine/threonine-protein kinase (c-Raf)(Y340D)(Y341D)
Type:Serine/threonine-protein kinase
Mol. Mass.:72984.33
Organism:Homo sapiens (Human)
Description:P04049 Y340D Y341D
Residue:648
Sequence:
MEHIQGAWKTISNGFGFKDAVFDGSSCISPTIVQQFGYQRRASDDGKLTDPSKTSNTIRV
FLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDAAS
LIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKV
PTMCVDWSNIRQLLLFPNSTIGDSGVPALPSLTMRRMRESVSRMPVSSQHRYSTPHAFTF
NTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIEDAIRSHSESASPSALSSSPNNL
SPTGWSQPKTPVPAQRERAPVSGTQEKNKIRPRGQRDSSDDWEIEASEVMLSTRIGSGSF
GTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIV
TQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGL
TVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYE
LMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFP
QILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLTTSPRLPVF
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM322540
NameBDBM322540
Synonyms:5-[3-(5-phenyl-1H-pyrazol-3-yl)chroman-6-yl]oxy-3,4-dihydro-1H-1,8-naphthyridin-2-one | US10183939, Example 18
TypeSmall organic molecule
Emp. Form.C26H22N4O3
Mol. Mass.438.4779
SMILESO=C1CCc2c(Oc3ccc4OCC(Cc4c3)c3cc([nH]n3)-c3ccccc3)ccnc2N1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a