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Target
Serine/threonine-protein kinase B-raf [416-766,V600E]
Ligand
BDBM322542
Substrate
n/a
Meas. Tech.
LanthaScreen Eu kinase binding assay
IC50
<4±n/a nM
Citation
 Bingham, M; Testar, R; Gignoux, C Fused bicyclic (hetero)aromatic compounds useful for the treatment of cancers US Patent  US10183939 Publication Date 1/22/2019 
Target
Name:
Serine/threonine-protein kinase B-raf [416-766,V600E]
Synonyms:
B-Raf (V600E) | BRAF | BRAF1 | BRAF_HUMAN | RAFB1
Type:
n/a
Mol. Mass.:
39690.71
Organism:
Homo sapiens (Human)
Description:
PV3849, from Invitrogen
Residue:
351
Sequence:
LQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATEKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH
  
Inhibitor
Name:
BDBM322542
Synonyms:
5-[[(3R)-3-(4-phenyl-1H-imidazol-2-yl)-2,3-dihydro-1,4-benzodioxin-6-yl]oxy]-3,4-dihydro-1H-1,8-naphthyridin-2-one | US10183939, Example 20 | USRE49361, Example 20
Type:
Small organic molecule
Emp. Form.:
C25H20N4O4
Mol. Mass.:
440.4507
SMILES:
O=C1CCc2c(Oc3ccc4OC[C@H](Oc4c3)c3nc(c[nH]3)-c3ccccc3)ccnc2N1 |r|
Structure:
Search PDB for entries with ligand similarity: