Reaction Details Report a problem with these data
Target
Cannabinoid receptor 2
Ligand
BDBM322989
Substrate
n/a
Meas. Tech.
cAMP Assay
EC50
131±n/a nM
Citation
 Grether, U; Nettekoven, M; Rogers-Evans, M; Schmitt, S; Stenton, BJ Triazolo[4,5-D]pyrimidines US Patent  US10183946 Publication Date 1/22/2019 
Target
Name:
Cannabinoid receptor 2
Synonyms:
CANNABINOID CB2 | CB-2 | CB2 | CB2A | CB2B | CNR2 | CNR2_HUMAN | CX5 | Cannabinoid CB2 receptor | Cannabinoid receptor 2 (CB2) | Cannabinoid receptor 2 (CB2R) | hCB2
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
39690.94
Organism:
Homo sapiens (Human)
Description:
P34972
Residue:
360
Sequence:
MEECWVTEIANGSKDGLDSNPMKDYMILSGPQKTAVAVLCTLLGLLSALENVAVLYLILSSHQLRRKPSYLFIGSLAGADFLASVVFACSFVNFHVFHGVDSKAVFLLKIGSVTMTFTASVGSLLLTAIDRYLCLRYPPSYKALLTRGRALVTLGIMWVLSALVSYLPLMGWTCCPRPCSELFPLIPNDYLLSWLLFIAFLFSGIIYTYGHVLWKAHQHVASLSGHQDRQVPGMARMRLDVRLAKTLGLVLAVLLICWFPVLALMAHSLATTLSDQVKKAFAFCSMLCLINSMVNPVIYALRSGEIRSSAHHCLAHWKKCVRGLGSEAKEEAPRSSVTETEADGKITPWPDSRDLDLSDC
  
Inhibitor
Name:
BDBM322989
Synonyms:
5-tert-butyl-7-(2-methylpyrazol-3-yl)-3-(3,3,3-trifluoropropyl)triazolo[4,5-d]pyrimidine | US10183946, Example 20
Type:
Small organic molecule
Emp. Form.:
C15H18F3N7
Mol. Mass.:
353.3455
SMILES:
Cn1nccc1-c1nc(nc2n(CCC(F)(F)F)nnc12)C(C)(C)C
Structure:
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