Reaction Details Report a problem with these data
Target
Cannabinoid receptor 1
Ligand
BDBM323010
Substrate
n/a
Meas. Tech.
cAMP Assay
EC50
>10000±n/a nM
Citation
 Grether, U; Nettekoven, M; Rogers-Evans, M; Schmitt, S; Stenton, BJ Triazolo[4,5-D]pyrimidines US Patent  US10183946 Publication Date 1/22/2019 
Target
Name:
Cannabinoid receptor 1
Synonyms:
CANN6 | CANNABINOID CB1 | CB-R | CB1 | CNR | CNR1 | CNR1_HUMAN | Cannabinoid CB1 receptor | Cannabinoid receptor | Cannabinoid receptor 1 (CB1) | Cannabinoid receptor 1 (brain)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
52868.96
Organism:
Homo sapiens (Human)
Description:
P21554
Residue:
472
Sequence:
MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL
  
Inhibitor
Name:
BDBM323010
Synonyms:
Cis-1-[5-tert-Butyl-3-[(2-chlorophenyl)methyl]triazolo[4,5-d]pyrimidin-7-yl]-3-(difluoromethyl)cyclobutanol | US10183946, Example 41
Type:
Small organic molecule
Emp. Form.:
C20H22ClF2N5O
Mol. Mass.:
421.871
SMILES:
CC(C)(C)c1nc(c2nnn(Cc3ccccc3Cl)c2n1)[C@@]1(O)C[C@@H](C1)C(F)F |r,wU:21.24,24.29,(-4.07,-4.07,;-4.07,-2.53,;-5.4,-1.76,;-5.4,-3.3,;-2.73,-1.76,;-2.73,-.22,;-1.4,.55,;-.07,-.22,;1.4,.25,;2.3,-.99,;1.4,-2.24,;1.4,-3.78,;2.73,-4.55,;2.73,-6.09,;4.07,-6.86,;5.4,-6.09,;5.4,-4.55,;4.07,-3.78,;4.07,-2.24,;-.07,-1.76,;-1.4,-2.53,;-1.4,2.09,;-2.73,1.32,;-.07,2.86,;-.84,4.19,;-2.17,3.42,;-.07,5.52,;1.47,5.52,;-.84,6.86,)|
Structure:
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