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Target
Arachidonate 5-lipoxygenase-activating protein
Ligand
BDBM323020
Substrate
n/a
Meas. Tech.
FLAP Binding Assay (Test A)
IC50
22.0±n/a nM
Citation
 Broddefalk, JO; Emtenäs, HF; Granberg, KL; Lemurell, MA; Pettersen, DT; Plowright, AT; Ulander, LJ Pyrazole derivatives useful as 5-lipoxygenase activating protein (FLAP) inhibitors US Patent  US10183947 Publication Date 1/22/2019 
Target
Name:
Arachidonate 5-lipoxygenase-activating protein
Synonyms:
5-lipoxygenase activating protein | 5-lipoxygenase-activating protein (FLAP) | 5-lipoxygenase/FLAP | AL5AP_HUMAN | ALOX5AP | FLAP | MK-886-binding protein
Type:
Enzyme
Mol. Mass.:
18159.90
Organism:
Homo sapiens (Human)
Description:
P20292
Residue:
161
Sequence:
MDQETVGNVVLLAIVTLISVVQNGFFAHKVEHESRTQNGRSFQRTGTLAFERVYTANQNCVDAYPTFLAVLWSAGLLCSQVPAAFAGLMYLFVRQKYFVGYLGERTQSTPGYIFGKRIILFLFLMSVAGIFNYYLIFFFGSDFENYIKTISTTISPLLLIP
  
Inhibitor
Name:
BDBM323020
Synonyms:
(1S,2S or 1R,2R)-N-(3-Cyano-1-methyl- 1H-pyrazol-4-yl)-2-[4-(3-methyl-1H- pyrazol-5- yl)benzoyl]cyclohexanecarboxamide | US10183947, Example 5a | US10183947, Example 5b
Type:
Small organic molecule
Emp. Form.:
C23H24N6O2
Mol. Mass.:
416.4757
SMILES:
Cc1cc([nH]n1)-c1ccc(cc1)C(=O)C1CCCCC1C(=O)Nc1cn(C)nc1C#N |w:19.22,14.15|
Structure:
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