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Target
Arachidonate 5-lipoxygenase-activating protein
Ligand
BDBM323034
Substrate
n/a
Meas. Tech.
FLAP Binding Assay (Test A)
IC50
28.0±n/a nM
Citation
 Broddefalk, JO; Emtenäs, HF; Granberg, KL; Lemurell, MA; Pettersen, DT; Plowright, AT; Ulander, LJ Pyrazole derivatives useful as 5-lipoxygenase activating protein (FLAP) inhibitors US Patent  US10183947 Publication Date 1/22/2019 
Target
Name:
Arachidonate 5-lipoxygenase-activating protein
Synonyms:
5-lipoxygenase activating protein | 5-lipoxygenase-activating protein (FLAP) | 5-lipoxygenase/FLAP | AL5AP_HUMAN | ALOX5AP | FLAP | MK-886-binding protein
Type:
Enzyme
Mol. Mass.:
18159.90
Organism:
Homo sapiens (Human)
Description:
P20292
Residue:
161
Sequence:
MDQETVGNVVLLAIVTLISVVQNGFFAHKVEHESRTQNGRSFQRTGTLAFERVYTANQNCVDAYPTFLAVLWSAGLLCSQVPAAFAGLMYLFVRQKYFVGYLGERTQSTPGYIFGKRIILFLFLMSVAGIFNYYLIFFFGSDFENYIKTISTTISPLLLIP
  
Inhibitor
Name:
BDBM323034
Synonyms:
(1R,2R or 1S,2S)-N-(5-Cyano-1-methyl- 1H-pyrazol-4-yl)-2-[4-(1H-pyrazol-3- yl)benzoyl]cyclohexanecarboxamide | US10183947, Example 18a | US10183947, Example 18b | US10508119, Example 18b
Type:
Small organic molecule
Emp. Form.:
C22H22N6O2
Mol. Mass.:
402.4491
SMILES:
Cn1ncc(NC(=O)C2CCCCC2C(=O)c2ccc(cc2)-c2cc[nH]n2)c1C#N |w:8.7,13.14|
Structure:
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