Reaction Details Report a problem with these data
Target
Arachidonate 5-lipoxygenase-activating protein
Ligand
BDBM323043
Substrate
n/a
Meas. Tech.
FLAP Binding Assay (Test A)
IC50
290±n/a nM
Citation
 Broddefalk, JO; Emtenäs, HF; Granberg, KL; Lemurell, MA; Pettersen, DT; Plowright, AT; Ulander, LJ Pyrazole derivatives useful as 5-lipoxygenase activating protein (FLAP) inhibitors US Patent  US10183947 Publication Date 1/22/2019 
Target
Name:
Arachidonate 5-lipoxygenase-activating protein
Synonyms:
5-lipoxygenase activating protein | 5-lipoxygenase-activating protein (FLAP) | 5-lipoxygenase/FLAP | AL5AP_HUMAN | ALOX5AP | FLAP | MK-886-binding protein
Type:
Enzyme
Mol. Mass.:
18159.90
Organism:
Homo sapiens (Human)
Description:
P20292
Residue:
161
Sequence:
MDQETVGNVVLLAIVTLISVVQNGFFAHKVEHESRTQNGRSFQRTGTLAFERVYTANQNCVDAYPTFLAVLWSAGLLCSQVPAAFAGLMYLFVRQKYFVGYLGERTQSTPGYIFGKRIILFLFLMSVAGIFNYYLIFFFGSDFENYIKTISTTISPLLLIP
  
Inhibitor
Name:
BDBM323043
Synonyms:
(1R,2R)-N-(1-Methyl-3-sulfamoyl-1H- pyrazol-4-yl)-2-[4-(1H-pyrazol-5- yl)benzoyl]cyclohexanecarboxamide | US10183947, Example 26 | US10508119, Example 26 | US11001589, Example 26 | US11691978, Example 26
Type:
Small organic molecule
Emp. Form.:
C21H24N6O4S
Mol. Mass.:
456.518
SMILES:
Cn1cc(NC(=O)[C@@H]2CCCC[C@H]2C(=O)c2ccc(cc2)-c2ccn[nH]2)c(n1)S(N)(=O)=O |r|
Structure:
Search PDB for entries with ligand similarity: