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Target
Arachidonate 5-lipoxygenase-activating protein
Ligand
BDBM323047
Substrate
n/a
Meas. Tech.
FLAP Binding Assay (Test A)
IC50
12.0±n/a nM
Citation
 Broddefalk, JO; Emtenäs, HF; Granberg, KL; Lemurell, MA; Pettersen, DT; Plowright, AT; Ulander, LJ Pyrazole derivatives useful as 5-lipoxygenase activating protein (FLAP) inhibitors US Patent  US10183947 Publication Date 1/22/2019 
Target
Name:
Arachidonate 5-lipoxygenase-activating protein
Synonyms:
5-lipoxygenase activating protein | 5-lipoxygenase-activating protein (FLAP) | 5-lipoxygenase/FLAP | AL5AP_HUMAN | ALOX5AP | FLAP | MK-886-binding protein
Type:
Enzyme
Mol. Mass.:
18159.90
Organism:
Homo sapiens (Human)
Description:
P20292
Residue:
161
Sequence:
MDQETVGNVVLLAIVTLISVVQNGFFAHKVEHESRTQNGRSFQRTGTLAFERVYTANQNCVDAYPTFLAVLWSAGLLCSQVPAAFAGLMYLFVRQKYFVGYLGERTQSTPGYIFGKRIILFLFLMSVAGIFNYYLIFFFGSDFENYIKTISTTISPLLLIP
  
Inhibitor
Name:
BDBM323047
Synonyms:
(1R,2R)-N-[5-(Difluoromethyl)-1H- pyrazol-4-yl]-2-[4-(1H-pyrazol-3- yl)benzoyl]cyclohexanecarboxamide | US10183947, Example 30 | US10508119, Example 30 | US11001589, Example 30 | US11691978, Example 30
Type:
Small organic molecule
Emp. Form.:
C21H21F2N5O2
Mol. Mass.:
413.4205
SMILES:
FC(F)c1[nH]ncc1NC(=O)[C@@H]1CCCC[C@H]1C(=O)c1ccc(cc1)-c1cc[nH]n1 |r|
Structure:
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