Reaction Details Report a problem with these data
Target
Arachidonate 5-lipoxygenase-activating protein
Ligand
BDBM323050
Substrate
n/a
Meas. Tech.
FLAP Binding Assay (Test A)
IC50
54.0±n/a nM
Citation
 Broddefalk, JO; Emtenäs, HF; Granberg, KL; Lemurell, MA; Pettersen, DT; Plowright, AT; Ulander, LJ Pyrazole derivatives useful as 5-lipoxygenase activating protein (FLAP) inhibitors US Patent  US10183947 Publication Date 1/22/2019 
Target
Name:
Arachidonate 5-lipoxygenase-activating protein
Synonyms:
5-lipoxygenase activating protein | 5-lipoxygenase-activating protein (FLAP) | 5-lipoxygenase/FLAP | AL5AP_HUMAN | ALOX5AP | FLAP | MK-886-binding protein
Type:
Enzyme
Mol. Mass.:
18159.90
Organism:
Homo sapiens (Human)
Description:
P20292
Residue:
161
Sequence:
MDQETVGNVVLLAIVTLISVVQNGFFAHKVEHESRTQNGRSFQRTGTLAFERVYTANQNCVDAYPTFLAVLWSAGLLCSQVPAAFAGLMYLFVRQKYFVGYLGERTQSTPGYIFGKRIILFLFLMSVAGIFNYYLIFFFGSDFENYIKTISTTISPLLLIP
  
Inhibitor
Name:
BDBM323050
Synonyms:
(1R,2R and 1S,2S)-N-(5-Cyclopropyl-1- methyl-1H-1,2,3-triazol-4-yl)-2-[4-(1H- pyrazol-5-yl)benzoyl] cyclohexanecarboxamide | US10183947, Example 33 | US10508119, Example 33
Type:
Small organic molecule
Emp. Form.:
C23H26N6O2
Mol. Mass.:
418.4915
SMILES:
Cn1nnc(NC(=O)C2CCCCC2C(=O)c2ccc(cc2)-c2ccn[nH]2)c1C1CC1 |w:8.7,13.14|
Structure:
Search PDB for entries with ligand similarity: