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Target
Serine/threonine-protein kinase Chk1
Ligand
BDBM323143
Substrate
n/a
Meas. Tech.
Kinase Inhibition Asssay
IC50
0.100±n/a nM
Citation
 Boyle, RG; Boyce, RJ Pharmaceutically active pyrazine derivatives US Patent  US9630931 Publication Date 4/25/2017 
Target
Name:
Serine/threonine-protein kinase Chk1
Synonyms:
CHEK1 | CHK1 | CHK1 checkpoint homolog | CHK1_HUMAN | Checkpoint kinase-1 (CHK1)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
54443.02
Organism:
Homo sapiens (Human)
Description:
gi_166295192
Residue:
476
Sequence:
MAVPFVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICINKMLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLKRREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLALLHKILVENPSARITIPDIKKDRWYNKPLKKGAKRPRVTSGGVSESPSGFSKHIQSNLDFSPVNSASSEENVKYSSSQPEPRTGLSLWDTSPSYIDKLVQGISFSQPTCPDHMLLNSQLLGTPGSSQNPWQRLVKRMTRFFTKLDADKSYQCLKETCEKLGYQWKKSCMNQVTISTTDRRNNKLIFKVNLLEMDDKILVDFRLSKGDGLEFKRHFLKIKGKLIDIVSSQKIWLPAT
  
Inhibitor
Name:
BDBM323143
Synonyms:
US9630931, Example 6
Type:
Small organic molecule
Emp. Form.:
C21H26ClN7O2
Mol. Mass.:
443.93
SMILES:
COc1cc(CCNC[C@@H]2CCCNC2)c(Cl)cc1NC(=O)Nc1cnc(cn1)C#N |r|
Structure:
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