Reaction Details Report a problem with these data
Target
Melanocortin receptor 4
Ligand
BDBM323260
Substrate
n/a
Meas. Tech.
Transactivation Assay
EC50
2000±n/a nM
Citation
 Bouix-Peter, C; Suzuki, I; Rodeville, N; Mauvais, P; Pascal, J Oxoazetidine derivatives, process for the preparation thereof and use thereof in human medicine and in cosmetics US Patent  US9630949 Publication Date 4/25/2017 
Target
Name:
Melanocortin receptor 4
Synonyms:
MC4-R | MC4R | MC4R_HUMAN | Melanocortin MC4 | Melanocortin receptor 4 (MC-4) | Melanocortin receptor 4 (MC4-R) | Melanocortin receptor 4 (MC4R)
Type:
Enzyme
Mol. Mass.:
36949.50
Organism:
Homo sapiens (Human)
Description:
P32245
Residue:
332
Sequence:
MVNSTHRGMHTSLHLWNRSSYRLHSNASESLGKGYSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVSGILFIIYSDSSAVIICLITMFFTMLALMASLYVHMFLMARLHIKRIAVLPGTGAIRQGANMKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPLIYALRSQELRKTFKEIICCYPLGGLCDLSSRY
  
Inhibitor
Name:
BDBM323260
Synonyms:
3-(1H-Imidazol-4-yl)-N-[(R)-1-(4-methoxybenzyl)-2-oxo-2-[3-o-tolyl-3-(4,4,4-trifluorobutoxy)azetidin-1-yl]ethyl]propionamide | US9630949, 78
Type:
Small organic molecule
Emp. Form.:
C30H35F3N4O4
Mol. Mass.:
572.6185
SMILES:
COc1ccc(C[C@@H](NC(=O)CCc2c[nH]cn2)C(=O)N2CC(C2)(OCCCC(F)(F)F)c2ccccc2C)cc1
Structure:
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