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Target
Hsp90 co-chaperone Cdc37
Ligand
BDBM279676
Substrate
n/a
Meas. Tech.
In Vitro Assay
IC50
5500±n/a nM
Citation
 Cai, X; Qian, C; Zhai, H Fused amino pyridine as HSP90 inhibitors US Patent  US9630965 Publication Date 4/25/2017 
Target
Name:
Hsp90 co-chaperone Cdc37
Synonyms:
CDC37 | CDC37A | CDC37_HUMAN | Hsp90 co-chaperone
Type:
Molecular Chaperone
Mol. Mass.:
44453.72
Organism:
Homo sapiens (Human)
Description:
Q16543
Residue:
378
Sequence:
MVDYSVWDHIEVSDDEDETHPNIDTASLFRWRHQARVERMEQFQKEKEELDRGCRECKRKVAECQRKLKELEVAEGGKAELERLQAEAQQLRKEERSWEQKLEEMRKKEKSMPWNVDTLSKDGFSKSMVNTKPEKTEEDSEEVREQKHKTFVEKYEKQIKHFGMLRRWDDSQKYLSDNVHLVCEETANYLVIWCIDLEVEEKCALMEQVAHQTIVMQFILELAKSLKVDPRACFRQFFTKIKTADRQYMEGFNDELEAFKERVRGRAKLRIEKAMKEYEEEERKKRLGPGGLDPVEVYESLPEELQKCFDVKDVQMLQDAISKMDPTDAKYHMQRCIDSGLWVPNSKASEAKEGEEAGPGDPLLEAVPKTGDEKDVSV
  
Inhibitor
Name:
BDBM279676
Synonyms:
US10035797, Compound 14 | US10428068, Compound 14 | US10844056, Compound 14 | US11560377, Compound 14 | US9630965, Compound 14
Type:
Small organic molecule
Emp. Form.:
C18H17ClN4OS
Mol. Mass.:
372.872
SMILES:
COc1ccc(Cl)c(Sc2nc3c(N)nccc3n2CCCC#C)c1
Structure:
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