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Target
Coagulation factor IX
Ligand
BDBM324193
Substrate
n/a
Meas. Tech.
Determination of Inhibitory Activity Against Factor IXa
IC50
544±n/a nM
Citation
 Zhang, T; Chen, Y; Guo, L; Hruza, A; Jian, T; Li, B; Meng, D; Parker, DL; Sherer, EC; Wood, HB; Sakurada, I Factor IXa inhibitors US Patent  US10189819 Publication Date 1/29/2019 
Target
Name:
Coagulation factor IX
Synonyms:
Christmas factor | Coagulation factor IX precursor | Coagulation factor IX/VIII | Coagulation factor IXa | Coagulation factor IXa heavy chain | Coagulation factor IXa light chain | F9 | FA9_HUMAN | Factor IX | Factor IXa | Factor IXa (fIXa) | PTC | Plasma thromboplastin component
Type:
Enzyme
Mol. Mass.:
51768.83
Organism:
Homo sapiens (Human)
Description:
P00740
Residue:
461
Sequence:
MQRVNMIMAESPGLITICLLGYLLSAECTVFLDHENANKILNRPKRYNSGKLEEFVQGNLERECMEEKCSFEEAREVFENTERTTEFWKQYVDGDQCESNPCLNGGSCKDDINSYECWCPFGFEGKNCELDVTCNIKNGRCEQFCKNSADNKVVCSCTEGYRLAENQKSCEPAVPFPCGRVSVSQTSKLTRAETVFPDVDYVNSTEAETILDNITQSTQSFNDFTRVVGGEDAKPGQFPWQVVLNGKVDAFCGGSIVNEKWIVTAAHCVETGVKITVVAGEHNIEETEHTEQKRNVIRIIPHHNYNAAINKYNHDIALLELDEPLVLNSYVTPICIADKEYTNIFLKFGSGYVSGWGRVFHKGRSALVLQYLRVPLVDRATCLRSTKFTIYNNMFCAGFHEGGRDSCQGDSGGPHVTEVEGTSFLTGIISWGEECAMKGKYGIYTKVSRYVNWIKEKTKLT
  
Inhibitor
Name:
BDBM324193
Synonyms:
US10189819, Example 23
Type:
Small organic molecule
Emp. Form.:
C31H26Cl2N4O3
Mol. Mass.:
573.469
SMILES:
COC(=O)c1ccc(cn1)-c1cc(Cl)c(C(=O)NCC(c2nc3cc(C)c(C)cc3[nH]2)c2ccccc2)c(Cl)c1
Structure:
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