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Target
Coagulation factor IX
Ligand
BDBM324194
Substrate
n/a
Meas. Tech.
Determination of Inhibitory Activity Against Factor IXa
IC50
141±n/a nM
Citation
 Zhang, T; Chen, Y; Guo, L; Hruza, A; Jian, T; Li, B; Meng, D; Parker, DL; Sherer, EC; Wood, HB; Sakurada, I Factor IXa inhibitors US Patent  US10189819 Publication Date 1/29/2019 
Target
Name:
Coagulation factor IX
Synonyms:
Christmas factor | Coagulation factor IX precursor | Coagulation factor IX/VIII | Coagulation factor IXa | Coagulation factor IXa heavy chain | Coagulation factor IXa light chain | F9 | FA9_HUMAN | Factor IX | Factor IXa | Factor IXa (fIXa) | PTC | Plasma thromboplastin component
Type:
Enzyme
Mol. Mass.:
51768.83
Organism:
Homo sapiens (Human)
Description:
P00740
Residue:
461
Sequence:
MQRVNMIMAESPGLITICLLGYLLSAECTVFLDHENANKILNRPKRYNSGKLEEFVQGNLERECMEEKCSFEEAREVFENTERTTEFWKQYVDGDQCESNPCLNGGSCKDDINSYECWCPFGFEGKNCELDVTCNIKNGRCEQFCKNSADNKVVCSCTEGYRLAENQKSCEPAVPFPCGRVSVSQTSKLTRAETVFPDVDYVNSTEAETILDNITQSTQSFNDFTRVVGGEDAKPGQFPWQVVLNGKVDAFCGGSIVNEKWIVTAAHCVETGVKITVVAGEHNIEETEHTEQKRNVIRIIPHHNYNAAINKYNHDIALLELDEPLVLNSYVTPICIADKEYTNIFLKFGSGYVSGWGRVFHKGRSALVLQYLRVPLVDRATCLRSTKFTIYNNMFCAGFHEGGRDSCQGDSGGPHVTEVEGTSFLTGIISWGEECAMKGKYGIYTKVSRYVNWIKEKTKLT
  
Inhibitor
Name:
BDBM324194
Synonyms:
US10189819, Example 24
Type:
Small organic molecule
Emp. Form.:
C31H25Cl2N5O2
Mol. Mass.:
570.469
SMILES:
Cc1cc2nc([nH]c2cc1C)C(CNC(=O)c1c(Cl)cc(cc1Cl)-c1cnc2C(=O)NCc2c1)c1ccccc1
Structure:
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