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Target
Serine/threonine-protein kinase B-raf [416-766,V600E]
Ligand
BDBM186811
Substrate
n/a
Meas. Tech.
Raf IC50 Assay
Temperature
298.15±n/a K
IC50
40000±n/a nM
Comments
extracted
Citation
 Zhou, C; Zhang, G Fused tricyclic urea compounds as Raf kinase and/or Raf kinase dimer inhibitors US Patent  US9670203 Publication Date 6/6/2017 
Target
Name:
Serine/threonine-protein kinase B-raf [416-766,V600E]
Synonyms:
B-Raf (V600E) | BRAF | BRAF1 | BRAF_HUMAN | RAFB1
Type:
n/a
Mol. Mass.:
39690.71
Organism:
Homo sapiens (Human)
Description:
PV3849, from Invitrogen
Residue:
351
Sequence:
LQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATEKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH
  
Inhibitor
Name:
BDBM186811
Synonyms:
US9670203, Compound 1.3
Type:
Small organic molecule
Emp. Form.:
C26H24N4O5
Mol. Mass.:
472.4926
SMILES:
COc1ccc(CNC(=O)N[C@@H]2[C@H]3Oc4ccc(Oc5ccnc6NC(=O)CCc56)cc4[C@@H]23)cc1 |r|
Structure:
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