Reaction Details Report a problem with these data
Target
Interstitial collagenase
Ligand
BDBM11553
Substrate
Fluorogenic Peptide Substrate
Meas. Tech.
MMP Inhibition Assay
pH
7.5±n/a
Temperature
298.15±n/a K
Ki
3166±n/a nM
Citation
 Cherney, RJ; Mo, R; Meyer, DT; Hardman, KD; Liu, RQ; Covington, MB; Qian, M; Wasserman, ZR; Christ, DD; Trzaskos, JM; Newton, RC; Decicco, CP Sultam hydroxamates as novel matrix metalloproteinase inhibitors. J Med Chem 47:2981-3 (2004) [PubMed]  Article 
Target
Name:
Interstitial collagenase
Synonyms:
CLG | Fibroblast collagenase | MMP1 | MMP1_HUMAN | Matrix metalloproteinase-1 | Matrix metalloproteinase-1 (MMP-1)
Type:
Enzyme
Mol. Mass.:
54010.26
Organism:
Homo sapiens (Human)
Description:
P03956
Residue:
469
Sequence:
MHSFPPLLLLLFWGVVSHSFPATLETQEQDVDLVQKYLEKYYNLKNDGRQVEKRRNSGPVVEKLKQMQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIENYTPDLPRADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGNLAHAFQPGPGIGGDAHFDEDERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSYTFSGDVQLAQDDIDGIQAIYGRSQNPVQPIGPQTPKACDSKLTFDAITTIRGEVMFFKDRFYMRTNPFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGYPKDIYSSFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFPGIGHKVDAVFMKDGFFYFFHGTRQYKFDPKTKRILTLQKANSWFNCRKN
  
Inhibitor
Name:
BDBM11553
Synonyms:
(3R)-2-[(4-tert-butyl-1,1-biphenyl-4-yl)methyl]-N-hydroxy-1,2-thiazinane-3-carboxamide 1,1-dioxide | (3R)-2-{[4-(4-tert-butylphenyl)phenyl]methyl}-N-hydroxy-1,1-dioxo-1,2-thiazinane-3-carboxamide | Sultam Hydroxamate 23c
Type:
Small organic molecule
Emp. Form.:
C22H28N2O4S
Mol. Mass.:
416.534
SMILES:
CC(C)(C)c1ccc(cc1)-c1ccc(CN2[C@H](CCCS2(=O)=O)C(=O)NO)cc1 |r|
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
Fluorogenic Peptide Substrate
Synonyms:
n/a
Type:
Peptide
Mol. Mass.:
2468.31
Organism:
n/a
Description:
n/a
Residue:
23
Sequence:
MCAPRLEGLYLEDPAALAARGNH