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Target
Collagenase 3
Ligand
BDBM11547
Substrate
Fluorogenic Peptide Substrate
Meas. Tech.
MMP Inhibition Assay
Ki
1055±n/a nM
Citation
 Cherney, RJ; Mo, R; Meyer, DT; Hardman, KD; Liu, RQ; Covington, MB; Qian, M; Wasserman, ZR; Christ, DD; Trzaskos, JM; Newton, RC; Decicco, CP Sultam hydroxamates as novel matrix metalloproteinase inhibitors. J Med Chem 47:2981-3 (2004) [PubMed]  Article 
Target
Name:
Collagenase 3
Synonyms:
MMP-13 | MMP13 | MMP13_HUMAN | Matrix metalloproteinase-13 | Matrix metalloproteinase-13 (MMP-13) | Matrix metalloproteinase-13 (MMP13)
Type:
Enzyme
Mol. Mass.:
53808.06
Organism:
Homo sapiens (Human)
Description:
P45452
Residue:
471
Sequence:
MHPGVLAAFLFLSWTHCRALPLPSGGDEDDLSEEDLQFAERYLRSYYHPTNLAGILKENAASSMTERLREMQSFFGLEVTGKLDDNTLDVMKKPRCGVPDVGEYNVFPRTLKWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTYTGKSHFMLPDDDVQGIQSLYGPGDEDPNPKHPKTPDKCDPSLSLDAITSLRGETMIFKDRFFWRLHPQQVDAELFLTKSFWPELPNRIDAAYEHPSHDLIFIFRGRKFWALNGYDILEGYPKKISELGLPKEVKKISAAVHFEDTGKTLLFSGNQVWRYDDTNHIMDKDYPRLIEEDFPGIGDKVDAVYEKNGYIYFFNGPIQFEYSIWSNRIVRVMPANSILWC
  
Inhibitor
Name:
BDBM11547
Synonyms:
2-[2-(1,1-biphenyl-4-yl)ethyl]-N-hydroxyisothiazolidine-3-carboxamide 1,1-dioxide | N-hydroxy-1,1-dioxo-2-[2-(4-phenylphenyl)ethyl]-1,2-thiazolidine-3-carboxamide | Sultam Hydroxamate 10
Type:
Small organic molecule
Emp. Form.:
C18H20N2O4S
Mol. Mass.:
360.427
SMILES:
ONC(=O)C1CCS(=O)(=O)N1CCc1ccc(cc1)-c1ccccc1
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
Fluorogenic Peptide Substrate
Synonyms:
n/a
Type:
Peptide
Mol. Mass.:
2468.31
Organism:
n/a
Description:
n/a
Residue:
23
Sequence:
MCAPRLEGLYLEDPAALAARGNH