Reaction Details Report a problem with these data
Target
Protein M2-1
Ligand
BDBM324648
Substrate
n/a
Meas. Tech.
Viral Cytopathic Effect (CPE) Assay
EC50
3.40±n/a nM
Citation
 Wang, L; Gao, L; Huang, M; Guo, L; Liang, C; Zhu, W; Feng, S; Zheng, X; Zhang, W; Wu, G; Wang, B; Yun, H Aza-oxo-indoles for the treatment and prophylaxis of respiratory syncytial virus infection US Patent  US10189838 Publication Date 1/29/2019 
Target
Name:
Protein M2-1
Synonyms:
Envelope-associated 22 kDa protein | M2-1 | M21_HRSVA | Matrix M2-1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
22163.59
Organism:
Human respiratory syncytial virus A (strain A2)
Description:
P04545
Residue:
194
Sequence:
MSRRNPCKFEIRGHCLNGKRCHFSHNYFEWPPHALLVRQNFMLNRILKSMDKSIDTLSEISGAAELDRTEEYALGVVGVLESYIGSINNITKQSACVAMSKLLTELNSDDIKKLRDNEELNSPKIRVYNTVISYIESNRKNNKQTIHLLKRLPADVLKKTIKNTLDIHKSITINNPKESTVSDTNDHAKNNDTT
  
Inhibitor
Name:
BDBM324648
Synonyms:
1'-({5-Chloro-7-fluoro-1-[2- (methylsulfonyl)ethyl]-1H-indol-2- yl}methyl)spiro[cyclopropane-1,3'- pyrrolo[2,3-c]pyridin]-2'(1'H)-one | US10189838, Example 1-12
Type:
Small organic molecule
Emp. Form.:
C21H19ClFN3O3S
Mol. Mass.:
447.91
SMILES:
CS(=O)(=O)CCn1c(CN2C(=O)C3(CC3)c3ccncc23)cc2cc(Cl)cc(F)c12
Structure:
Search PDB for entries with ligand similarity: