Reaction Details Report a problem with these data
Target
Tumor necrosis factor
Ligand
BDBM324770
Substrate
n/a
Meas. Tech.
TNF induced HEK-Blue assay
IC50
<1000±n/a nM
Citation
 Xiao, H; Dhar, MT; Duan, J; Jiang, B; Tebben, AJ Substituted tricyclic heterocyclic compounds US Patent  US10189840 Publication Date 1/29/2019 
Target
Name:
Tumor necrosis factor
Synonyms:
Cachectin | TNF | TNF-a | TNF-alpha | TNFA | TNFA_HUMAN | TNFSF2 | Tumor necrosis factor (TNF-alpha) | Tumor necrosis factor (TNFa) | Tumor necrosis factor alpha (TNFα) | Tumor necrosis factor ligand superfamily member 2 | Tumor necrosis factor, membrane form | Tumor necrosis factor, soluble form | tumor necrosis factor alpha
Type:
Enzyme
Mol. Mass.:
25645.11
Organism:
Homo sapiens (Human)
Description:
P01375
Residue:
233
Sequence:
MSTESMIRDVELAEEALPKKTGGPQGSRRCLFLSLFSFLIVAGATTLFCLLHFGVIGPQREEFPRDLSLISPLAQAVRSSSRTPSDKPVAHVVANPQAEGQLQWLNRRANALLANGVELRDNQLVVPSEGLYLIYSQVLFKGQGCPSTHVLLTHTISRIAVSYQTKVNLLSAIKSPCQRETPEGAEAKPWYEPIYLGGVFQLEKGDRLSAEINRPDYLDFAESGQVYFGIIAL
  
Inhibitor
Name:
BDBM324770
Synonyms:
US10189840, Example 16
Type:
Small organic molecule
Emp. Form.:
C23H20F3N5O2
Mol. Mass.:
455.4324
SMILES:
CC(C)(O)c1ncc(cn1)-c1ccc2nc3C(F)CC(c4ccccc4OC(F)F)n3c2n1 |w:19.20,16.17|
Structure:
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