Reaction Details Report a problem with these data
Target
Tumor necrosis factor
Ligand
BDBM324774
Substrate
n/a
Meas. Tech.
TNF induced HEK-Blue assay
IC50
<1000±n/a nM
Citation
 Xiao, H; Dhar, MT; Duan, J; Jiang, B; Tebben, AJ Substituted tricyclic heterocyclic compounds US Patent  US10189840 Publication Date 1/29/2019 
Target
Name:
Tumor necrosis factor
Synonyms:
Cachectin | TNF | TNF-a | TNF-alpha | TNFA | TNFA_HUMAN | TNFSF2 | Tumor necrosis factor (TNF-alpha) | Tumor necrosis factor (TNFa) | Tumor necrosis factor alpha (TNFα) | Tumor necrosis factor ligand superfamily member 2 | Tumor necrosis factor, membrane form | Tumor necrosis factor, soluble form | tumor necrosis factor alpha
Type:
Enzyme
Mol. Mass.:
25645.11
Organism:
Homo sapiens (Human)
Description:
P01375
Residue:
233
Sequence:
MSTESMIRDVELAEEALPKKTGGPQGSRRCLFLSLFSFLIVAGATTLFCLLHFGVIGPQREEFPRDLSLISPLAQAVRSSSRTPSDKPVAHVVANPQAEGQLQWLNRRANALLANGVELRDNQLVVPSEGLYLIYSQVLFKGQGCPSTHVLLTHTISRIAVSYQTKVNLLSAIKSPCQRETPEGAEAKPWYEPIYLGGVFQLEKGDRLSAEINRPDYLDFAESGQVYFGIIAL
  
Inhibitor
Name:
BDBM324774
Synonyms:
US10189840, Example 20
Type:
Small organic molecule
Emp. Form.:
C24H24FN5O
Mol. Mass.:
417.4787
SMILES:
Cc1ccc(C)c(c1)C1CC(F)c2nc3ccc(nc3n12)-c1cnc(nc1)C(C)(C)O |w:8.8,10.11|
Structure:
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