Reaction Details Report a problem with these data
Target
5-hydroxytryptamine receptor 4
Ligand
BDBM325587
Substrate
n/a
Meas. Tech.
Cell-Based Assay
EC50
60.0±n/a nM
Citation
 Nirogi, R; Mohammed, AR; Yarlagadda, S; Ravella, SR; Shinde, AK; Kambhampati, R; Roayapalley, PK; Jayarajan, P; Bhyrapuneni, G; Patnala, SM; Ravula, J; Jasti, V Heteroaryl compounds as 5-HT4 receptor ligands US Patent  US9636335 Publication Date 5/2/2017 
Target
Name:
5-hydroxytryptamine receptor 4
Synonyms:
5-HT-4 | 5-HT4 | 5-HT4S | 5-HT4a | 5-HT4b | 5-HT4c | 5-HT4d | 5-HT4hb | 5-hydroxytryptamine receptor 4 | 5-hydroxytryptamine receptor 4 (5-HT4) | 5HT4R_HUMAN | HTR4 | Serotonin (5-HT) receptor | Serotonin (5-HT3) receptor | Serotonin 4 (5-HT4) receptor | Serotonin Receptor 4
Type:
Enzyme
Mol. Mass.:
43767.54
Organism:
Homo sapiens (Human)
Description:
Q13639
Residue:
388
Sequence:
MDKLDANVSSEEGFGSVEKVVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNSTYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQIQMLQRAGASSESRPQSADQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRRPSILGQTVPCSTTTINGSTHVLRDAVECGGQWESQCHPPATSPLVAAQPSDT
  
Inhibitor
Name:
BDBM325587
Synonyms:
5-Chloro-7-[5-(1-cyclopropyl-piperidin-4-yl)-[1,3,4]oxadiazol-2-yl]-2,3-dihydro-benzofuran-4-ylamine | US9636335, 27
Type:
Small organic molecule
Emp. Form.:
C18H21ClN4O2
Mol. Mass.:
360.838
SMILES:
Nc1c2CCOc2c(cc1Cl)-c1nnc(o1)C1CCN(CC1)C1CC1
Structure:
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