Reaction Details Report a problem with these data
Target
Muscarinic acetylcholine receptor M3
Ligand
BDBM325650
Substrate
n/a
Meas. Tech.
M3 Binding Assay
IC50
<1±n/a nM
Citation
 Amari, G; Armani, E; Blackaby, W; Van De Poeol, H; Baker-Glenn, C; Trivedi, N Aminoester derivatives US Patent  US9636336 Publication Date 5/2/2017 
Target
Name:
Muscarinic acetylcholine receptor M3
Synonyms:
ACM3_HUMAN | CHRM3 | Cholinergic, muscarinic M3 | Muscarinic Receptors M3 | Muscarinic receptor M3 | RecName: Full=Muscarinic acetylcholine receptor M3
Type:
Enzyme
Mol. Mass.:
66151.03
Organism:
Homo sapiens (Human)
Description:
P20309
Residue:
590
Sequence:
MTLHNNSTTSPLFPNISSSWIHSPSDAGLPPGTVTHFGSYNVSRAAGNFSSPDGTTDDPLGGHTVWQVVFIAFLTGILALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLWLAIDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTTKRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTVPPGECFIQFLSEPTITFGTAIAAFYMPVTIMTILYWRIYKETEKRTKELAGLQASGTEAETENFVHPTGSSRSCSSYELQQQSMKRSNRRKYGRCHFWFTTKSWKPSSEQMDQDHSSSDSWNNNDAAASLENSASSDEEDIGSETRAIYSIVLKLPGHSTILNSTKLPSSDNLQVPEEELGMVDLERKADKLQAQKSVDDGGSFPKSFSKLPIQLESAVDTAKTSDVNSSVGKSTATLPLSFKEATLAKRFALKTRSQITKRKRMSLVKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTFWNLGYWLCYINSTVNPVCYALCNKTFRTTFKMLLLCQCDKKKRRKQQYQQRQSVIFHKRAPEQAL
  
Inhibitor
Name:
BDBM325650
Synonyms:
US9636336, Example 44 | US9636336, Example 45 | [(1S)-1-[3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl]-2-(3,5-dichloro-1-oxido-pyridin-1-ium-4-yl)ethyl]5-[[[2-oxo-1-phenyl-2-(quinuclidin-4-ylmethoxy)ethyl]amino]methyl]thiophene-2-carboxylate
Type:
Small organic molecule
Emp. Form.:
C40H41Cl2F2N3O7S
Mol. Mass.:
816.737
SMILES:
[O-][n+]1cc(Cl)c(C[C@H](OC(=O)c2ccc(CNC(C(=O)OCC34CCN(CC3)CC4)c3ccccc3)s2)c2ccc(OC(F)F)c(OCC3CC3)c2)c(Cl)c1
Structure:
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