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Target
Isoform PDE4B2 of cAMP-specific 3',5'-cyclic phosphodiesterase 4B (PDE4B2)
Ligand
BDBM325652
Substrate
n/a
Meas. Tech.
HTRF Assay
IC50
5.5±n/a nM
Citation
 Amari, G; Armani, E; Blackaby, W; Van De Poeol, H; Baker-Glenn, C; Trivedi, N Aminoester derivatives US Patent  US9636336 Publication Date 5/2/2017 
Target
Name:
Isoform PDE4B2 of cAMP-specific 3',5'-cyclic phosphodiesterase 4B (PDE4B2)
Synonyms:
DPDE4 | PDE4B | PDE4B2 | PDE4B_HUMAN | cAMP-specific 3',5'-cyclic phosphodiesterase 4B (PDE4B2) | phosphodiesterase 4B2
Type:
Enzyme
Mol. Mass.:
64320.36
Organism:
Homo sapiens (Human)
Description:
Q07343-2
Residue:
564
Sequence:
MKEHGGTFSSTGISGGSGDSAMDSLQPLQPNYMPVCLFAEESYQKLAMETLEELDWCLDQLETIQTYRSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLDKQNDVEIPSPTQKDREKKKKQQLMTQISGVKKLMHSSSLNNTSISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQSMIPQSPSPPLDEQNRDCQGLMEKFQFELTLDEEDSEGPEKEGEGHSYFSSTKTLCVIDPENRDSLGETDIDIATEDKSPVDT
  
Inhibitor
Name:
BDBM325652
Synonyms:
US9636336, Example 46 | [(1S)-1-[3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl]-2-(3,5-dichloro-1-oxido-pyridin-1-ium-4-yl)ethyl]5-[[[1-(3-hydroxyphenyl)-2-[(1-methyl-4-piperidyl)methoxy]-2-oxo-ethyl]amino]methyl]thiophene-2-carboxylate
Type:
Small organic molecule
Emp. Form.:
C39H41Cl2F2N3O8S
Mol. Mass.:
820.726
SMILES:
CN1CCC(COC(=O)C(NCc2ccc(s2)C(=O)O[C@@H](Cc2c(Cl)c[n+]([O-])cc2Cl)c2ccc(OC(F)F)c(OCC3CC3)c2)c2cccc(O)c2)CC1
Structure:
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