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TargetMetabotropic glutamate receptor 2
LigandBDBM212881
Substrate/Competitorn/a
Meas. Tech.Biological Assay
IC50 17.0±n/a nM
Citation Bungard, CJConverso, ADe Leon, PHanney, BHartingh, TJManikowski, JJManley, PJMeissner, RMeng, ZPerkins, JJRudd, MTShu, Y Quinoline carboxamide and quinoline carbonitrile derivatives as mGluR2-negative allosteric modulators, compositions, and their use US Patent US9636337 Publication Date 5/2/2017
More Info.:Get all data from this article,  Assay Method
 
Metabotropic glutamate receptor 2
Name:Metabotropic glutamate receptor 2
Synonyms:GRM2 | Metabotropic glutamate receptor | glutamate receptor, metabotropic 2 precursor | mGlu2 | mGluR2 | metabotropic glutamate 2
Type:Enzyme
Mol. Mass.:95584.88
Organism:Homo sapiens (Human)
Description:Q14416
Residue:872
Sequence:
MGSLLALLALLLLWGAVAEGPAKKVLTLEGDLVLGGLFPVHQKGGPAEDCGPVNEHRGIQ
RLEAMLFALDRINRDPHLLPGVRLGAHILDSCSKDTHALEQALDFVRASLSRGADGSRHI
CPDGSYATHGDAPTAITGVIGGSYSDVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDY
FARTVPPDFFQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFELEARARNICVATSEK
VGRAMSRAAFEGVVRALLQKPSARVAVLFTRSEDARELLAASQRLNASFTWVASDGWGAL
ESVVAGSEGAAEGAITIELASYPISDFASYFQSLDPWNNSRNPWFREFWEQRFRCSFRQR
DCAAHSLRAVPFEQESKIMFVVNAVYAMAHALHNMHRALCPNTTRLCDAMRPVNGRRLYK
DFVLNVKFDAPFRPADTHNEVRFDRFGDGIGRYNIFTYLRAGSGRYRYQKVGYWAEGLTL
DTSLIPWASPSAGPLPASRCSEPCLQNEVKSVQPGEVCCWLCIPCQPYEYRLDEFTCADC
GLGYWPNASLTGCFELPQEYIRWGDAWAVGPVTIACLGALATLFVLGVFVRHNATPVVKA
SGRELCYILLGGVFLCYCMTFIFIAKPSTAVCTLRRLGLGTAFSVCYSALLTKTNRIARI
FGGAREGAQRPRFISPASQVAICLALISGQLLIVVAWLVVEAPGTGKETAPERREVVTLR
CNHRDASMLGSLAYNVLLIALCTLYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIF
YVTSSDYRVQTTTMCVSVSLSGSVVLGCLFAPKLHIILFQPQKNVVSHRAPTSRFGSAAA
RASSSLGQGSGSQFVPTVCNGREVVDSTTSSL
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  Blast E-value cutoff:
BDBM212881
NameBDBM212881
Synonyms:US9278960, 2-28 | US9663506, Example 2-28
TypeSmall organic molecule
Emp. Form.C22H25N3O3
Mol. Mass.379.4522
SMILESCC1CCC(CC1)c1cc(nc2cc(CN3C(=O)CCC3=O)ccc12)C(N)=O |(2.52,-5.39,;2.52,-3.85,;1.18,-3.08,;1.18,-1.54,;2.52,-.77,;3.85,-1.54,;3.85,-3.08,;2.52,.77,;3.85,1.54,;3.85,3.08,;2.52,3.85,;1.18,3.08,;-.15,3.85,;-1.48,3.08,;-2.82,3.85,;-4.15,3.08,;-4.15,1.54,;-2.82,.77,;-5.61,1.06,;-6.52,2.31,;-5.61,3.56,;-6.38,4.89,;-1.48,1.54,;-.15,.77,;1.18,1.54,;5.19,3.85,;6.52,3.08,;5.19,5.39,)|
Structure
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