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Target
Cytochrome P450 11B1, mitochondrial
Ligand
BDBM325762
Substrate
n/a
Meas. Tech.
G402-Based Assay
EC50
194±n/a nM
Citation
 Aebi, J; Amrein, K; Britton, R; Hornsperger, B; Kuhn, B; Maerki, HP; Martin, RE; Mayweg, AV; Tan, X Phenyl-dihydropyridine derivatives as aldosterone synthase inhibitors US Patent  US9636339 Publication Date 5/2/2017 
Target
Name:
Cytochrome P450 11B1, mitochondrial
Synonyms:
C11B1_HUMAN | CYP11B1 | CYPXIB1 | Cytochrome P450 11B, mitochondrial precursor | Cytochrome P450 11B1 | Cytochrome P450 11B1 (CYP11B1) | Cytochrome P450 11B1, mitochondrial | S11BH
Type:
Enzyme
Mol. Mass.:
57591.44
Organism:
Homo sapiens (Human)
Description:
P15538
Residue:
503
Sequence:
MALRAKAEVCMAVPWLSLQRAQALGTRAARVPRTVLPFEAMPRRPGNRWLRLLQIWREQGYEDLHLEVHQTFQELGPIFRYDLGGAGMVCVMLPEDVEKLQQVDSLHPHRMSLEPWVAYRQHRGHKCGVFLLNGPEWRFNRLRLNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWTSPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFSRPQQYTSIVAELLLNAELSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQEDIKMVYSFILRPSMFPLLTFRAIN
  
Inhibitor
Name:
BDBM325762
Synonyms:
(rac)-2-[4-[3-Fluoro-4-(trifluoromethyl)phenyl]-6,7-dihydro-5H-cyclopenta[c]pyridin-7-yl]-N-(1-methylpyrazol-4-yl)acetamide | US9636339, 12
Type:
Small organic molecule
Emp. Form.:
C21H18F4N4O
Mol. Mass.:
418.3874
SMILES:
Cn1cc(NC(=O)CC2CCc3c2cncc3-c2ccc(c(F)c2)C(F)(F)F)cn1
Structure:
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