Target
Nuclear receptor ROR-gamma [262-507]
Ligand
BDBM325787
Substrate
n/a
Meas. Tech.
SPA Binding Assay
IC50
57.0±n/a nM
Citation
 Duan, JDhar, TGJiang, BKarmakar, AGupta, AKLu, Z Heterocyclic sulfone RORγ modulators US Patent  US9637455 Publication Date 5/2/2017 
Target
Name:
Nuclear receptor ROR-gamma [262-507]
Synonyms:
NR1F3 | Nuclear receptor ROR-gamma | Nuclear receptor ROR-gamma (aa 262-507) | ROR-gamma (A262-S507) | RORC | RORG | RORG_HUMAN | RZRG
Type:
Enzyme Catalytic Domain
Mol. Mass.:
28605.37
Organism:
Homo sapiens (Human)
Description:
aa 262-507
Residue:
246
Sequence:
APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS
  
Inhibitor
Name:
BDBM325787
Synonyms:
1-(4-(4-(2-((2,6-difluorobenzyl)oxy)-1,1,1,3,3,3-hexafluoropropan-2-yl)phenyl)-4-((4-fluorophenyl)sulfonyl)piperidin-1-yl)-2-(tetrahydro-2H-pyran-4-yl)ethanone | US9637455, 4
Type:
Small organic molecule
Emp. Form.:
C34H32F9NO5S
Mol. Mass.:
737.672
SMILES:
Fc1ccc(cc1)S(=O)(=O)C1(CCN(CC1)C(=O)CC1CCOCC1)c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F
Structure:
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