Reaction Details Report a problem with these data
Target
Nuclear receptor ROR-gamma [262-507]
Ligand
BDBM325791
Substrate
n/a
Meas. Tech.
SPA Binding Assay
IC50
166±n/a nM
Citation
 Duan, J; Dhar, TG; Jiang, B; Karmakar, A; Gupta, AK; Lu, Z Heterocyclic sulfone RORγ modulators US Patent  US9637455 Publication Date 5/2/2017 
Target
Name:
Nuclear receptor ROR-gamma [262-507]
Synonyms:
NR1F3 | Nuclear receptor ROR-gamma | Nuclear receptor ROR-gamma (aa 262-507) | ROR-gamma (A262-S507) | RORC | RORG | RORG_HUMAN | RZRG
Type:
Enzyme Catalytic Domain
Mol. Mass.:
28605.37
Organism:
Homo sapiens (Human)
Description:
aa 262-507
Residue:
246
Sequence:
APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS
  
Inhibitor
Name:
BDBM325791
Synonyms:
US9637455, 7
Type:
Small organic molecule
Emp. Form.:
C35H28F9NO4S
Mol. Mass.:
729.652
SMILES:
Fc1ccc(cc1)S(=O)(=O)C1(CCN(CC1)C(=O)Cc1ccccc1)c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F
Structure:
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