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TargetDipeptidyl peptidase IV
LigandBDBM11642
Substrate/CompetitorBDBM11057
Meas. Tech.DPP Inhibition Assay
pH7.5±n/a
Temperature295.15±n/a K
Ki 12±n/a nM
Citation Longenecker, KLStewart, KDMadar, DJJakob, CGFry, EHWilk, SLin, CWBallaron, SJStashko, MALubben, THYong, HPireh, DPei, ZBasha, FWiedeman, PEvon Geldern, TWTrevillyan, JMStoll, VS Crystal structures of DPP-IV (CD26) from rat kidney exhibit flexible accommodation of peptidase-selective inhibitors. Biochemistry45:7474-82 (2006) [PubMed]  Article
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Dipeptidyl peptidase IV
Name:Dipeptidyl peptidase IV
Synonyms:Bile canaliculus domain-specific membrane glycoprotein | CD_antigen=CD26 | DPP IV | Dipeptidyl Peptidase IV (DPP-IV) | Dipeptidyl peptidase 4 | Dipeptidyl peptidase 4 (DDPIV) | Dipeptidyl peptidase 4 60 kDa soluble form | Dipeptidyl peptidase 4 membrane form | Dipeptidyl peptidase 4 soluble form | Dipeptidyl peptidase IV 60 kDa soluble form | Dipeptidyl peptidase IV membrane form | Dipeptidyl peptidase IV soluble form | GP110 glycoprotein | T-cell activation antigen CD26
Type:Enzyme
Mol. Mass.:88084.94
Organism:Rattus norvegicus (rat)
Description:n/a
Residue:767
Sequence:
MKTPWKVLLGLLGVAALVTIITVPVVLLNKDEAAADSRRTYTLADYLKNTFRVKSYSLRW
VSDSEYLYKQENNILLFNAEHGNSSIFLENSTFEIFGDSISDYSVSPDRLFVLLEYNYVK
QWRHSYTASYSIYDLNKRQLITEEKIPNNTQWITWSQEGHKLAYVWKNDIYVKIEPHLPS
HRITSTGKENVIFNGINDWVYEEEIFGAYSALWWSPNGTFLAYAQFNDTGVPLIEYSFYS
DESLQYPKTVWIPYPKAGAVNPTVKFFIVNTDSLSSTTTTIPMQITAPASVTTGDHYLCD
VAWVSEDRISLQWLRRIQNYSVMAICDYDKTTLVWNCPTTQEHIETSATGWCGRFRPAEP
HFTSDGSSFYKIVSDKDGYKHICQFQKDRKPEQVCTFITKGAWEVISIEALTSDYLYYIS
NEYKEMPGGRNLYKIQLTDHTNKKCLSCDLNPERCQYYSVSLSKEAKYYQLGCRGPGLPL
YTLHRSTDQKELRVLEDNSALDKMLQDVQMPSKKLDFIVLNETRFWYQMILPPHFDKSKK
YPLLIDVYAGPCSQKADAAFRLNWATYLASTENIIVASFDGRGSGYQGDKIMHAINKRLG
TLEVEDQIEAARQFLKMGFVDSKRVAIWGWSYGGYVTSMVLGSGSGVFKCGIAVAPVSRW
EYYDSVYTERYMGLPTPEDNLDHYRNSTVMSRAENFKQVEYLLIHGTADDNVHFQQSAQI
SKALVDAGVDFQAMWYTDEDHGIASSTAHQHIYSHMSHFLQQCFSLR
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BDBM11642
NameBDBM11642
Synonyms:(2S,5R)-1-[(2S)-2-amino-2-cyclopentylacetyl]-5-ethynylpyrrolidine-2-carbonitrile | (2S,5R)-1-[(2S)-2-amino-2-cyclopentylethanoyl]-5-ethynylpyrrolidine-2-carbonitrile | C5-substituted pyrrolidine 16 | alkynyl cyanopyrrolidine 1
TypeSmall organic molecule
Emp. Form.C14H19N3O
Mol. Mass.245.3202
SMILESN[C@@H](C1CCCC1)C(=O)N1[C@H](CC[C@H]1C#N)C#C |r|
Structure
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BDBM11057
NameBDBM11057
Synonyms:1-(2-aminoacetyl)-N-(4-methyl-2-oxo-2H-chromen-7-yl)pyrrolidine-2-carboxamide hydrobromide | Gly-Pro-7-amido-4-methylcoumarin hydrobromide | Gly-Pro-7-amidomethylcoumarin | Gly-Pro-AMC
TypeSmall organic molecule
Emp. Form.C17H19N3O4
Mol. Mass.329.3505
SMILESCc1cc(=O)oc2cc(NC(=O)C3CCCN3C(=O)CN)ccc12
Structure
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