Reaction Details Report a problem with these data
Target
Dipeptidyl peptidase 8
Ligand
BDBM11642
Substrate
BDBM11057
Meas. Tech.
DPP Inhibition Assay
pH
7.5±n/a
Temperature
295.15±n/a K
Ki
17700±n/a nM
Citation
 Longenecker, KL; Stewart, KD; Madar, DJ; Jakob, CG; Fry, EH; Wilk, S; Lin, CW; Ballaron, SJ; Stashko, MA; Lubben, TH; Yong, H; Pireh, D; Pei, Z; Basha, F; Wiedeman, PE; von Geldern, TW; Trevillyan, JM; Stoll, VS Crystal structures of DPP-IV (CD26) from rat kidney exhibit flexible accommodation of peptidase-selective inhibitors. Biochemistry 45:7474-82 (2006) [PubMed]  Article 
Target
Name:
Dipeptidyl peptidase 8
Synonyms:
DPP8 | DPP8_HUMAN | DPRP-1 | DPRP1 | Dipeptidyl peptidase 8 (DPP-8) | Dipeptidyl peptidase 8 (DPP8) | Dipeptidyl peptidase 8/9 | Dipeptidyl peptidase IV-related protein 1 | Dipeptidyl peptidase VIII | Dipeptidyl peptidase VIII (DDP-VIII) | Prolyl dipeptidase DPP8
Type:
Enzyme
Mol. Mass.:
103342.62
Organism:
Homo sapiens (Human)
Description:
Q6V1X1
Residue:
898
Sequence:
MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI
  
Inhibitor
Name:
BDBM11642
Synonyms:
(2S,5R)-1-[(2S)-2-amino-2-cyclopentylacetyl]-5-ethynylpyrrolidine-2-carbonitrile | (2S,5R)-1-[(2S)-2-amino-2-cyclopentylethanoyl]-5-ethynylpyrrolidine-2-carbonitrile | C5-substituted pyrrolidine 16 | alkynyl cyanopyrrolidine 1
Type:
Small organic molecule
Emp. Form.:
C14H19N3O
Mol. Mass.:
245.3202
SMILES:
N[C@@H](C1CCCC1)C(=O)N1[C@H](CC[C@H]1C#N)C#C |r|
Structure:
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Substrate
Name:
BDBM11057
Synonyms:
1-(2-aminoacetyl)-N-(4-methyl-2-oxo-2H-chromen-7-yl)pyrrolidine-2-carboxamide hydrobromide | Gly-Pro-7-amido-4-methylcoumarin hydrobromide | Gly-Pro-7-amidomethylcoumarin | Gly-Pro-AMC
Type:
Small organic molecule
Emp. Form.:
C17H19N3O4
Mol. Mass.:
329.3505
SMILES:
Cc1cc(=O)oc2cc(NC(=O)C3CCCN3C(=O)CN)ccc12
Structure:
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