Reaction Details Report a problem with these data
Target
Solute carrier family 22 member 12
Ligand
BDBM50134674
Substrate
n/a
Meas. Tech.
In Vitro Assay
IC50
359±n/a nM
Citation
 Peng, J; Sun, P; Lan, J; Gu, C; Li, X; Liu, B; Han, C; Hu, Q; Jin, F; Dong, Q; Cao, G Cycloalkyl acid derivative, preparation method thereof, and pharmaceutical application thereof US Patent  US9637484 Publication Date 5/2/2017 
Target
Name:
Solute carrier family 22 member 12
Synonyms:
OATL4 | Organic anion transporter 4-like protein | RST | Renal-specific transporter | S22AC_HUMAN | SLC22A12 | Solute carrier family 22 member 12 | Solute carrier family 22 member 12 (URAT1) | URAT1 | Urate anion exchanger 1 | Urate anion exchanger 1 (URAT1) | Uric Acid Transporter 1 (URAT1)
Type:
Enzyme
Mol. Mass.:
59638.65
Organism:
Homo sapiens (Human)
Description:
Q96S37
Residue:
553
Sequence:
MAFSELLDLVGGLGRFQVLQTMALMVSIMWLCTQSMLENFSAAVPSHRCWAPLLDNSTAQASILGSLSPEALLAISIPPGPNQRPHQCRRFRQPQWQLLDPNATATSWSEADTEPCVDGWVYDRSIFTSTIVAKWNLVCDSHALKPMAQSIYLAGILVGAAACGPASDRFGRRLVLTWSYLQMAVMGTAAAFAPAFPVYCLFRFLLAFAVAGVMMNTGTLLMEWTAARARPLVMTLNSLGFSFGHGLTAAVAYGVRDWTLLQLVVSVPFFLCFLYSWWLAESARWLLTTGRLDWGLQELWRVAAINGKGAVQDTLTPEVLLSAMREELSMGQPPASLGTLLRMPGLRFRTCISTLCWFAFGFTFFGLALDLQALGSNIFLLQMFIGVVDIPAKMGALLLLSHLGRRPTLAASLLLAGLCILANTLVPHEMGALRSALAVLGLGGVGAAFTCITIYSSELFPTVLRMTAVGLGQMAARGGAILGPLVRLLGVHGPWLPLLVYGTVPVLSGLAALLLPETQSLPLPDTIQDVQNQAVKKATHGTLGNSVLKSTQF
  
Inhibitor
Name:
BDBM50134674
Synonyms:
CHEMBL3747747 | US9637484, 8
Type:
Small organic molecule
Emp. Form.:
C21H16F3NO2S
Mol. Mass.:
403.417
SMILES:
OC(=O)C1(CCC1)Sc1ccnc2ccc(cc12)-c1cccc(c1)C(F)(F)F
Structure:
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